Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

Design, Synthesis and Stability of N-Acyloxymethyl- and N-Aminocarbonyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors

2001 ◽  
Vol 11 (8) ◽  
pp. 1065-1068 ◽  
Author(s):  
A Clemente ◽  
A Domingos ◽  
A.P Grancho ◽  
J Iley ◽  
R Moreira ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold

2004 ◽  
Vol 12 (3) ◽  
pp. 589-593 ◽  
Author(s):  
Jiaying Zhong ◽  
Xiangdong Gan ◽  
Kevin R Alliston ◽  
William C Groutas
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Human Leukocyte Elastase

Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners

1996 ◽  
Vol 4 (9) ◽  
pp. 1393-1400 ◽  
Author(s):  
William C. Groutas ◽  
Jeffrey B. Epp ◽  
Radhika Venkataraman ◽  
Rongze Kuang ◽  
Tien My Truong ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Human Leukocyte ◽  
Cathepsin G ◽  
Proteinase 3 ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of .beta.-carbolinone-containing trifluoromethyl ketones

1995 ◽  
Vol 38 (1) ◽  
pp. 86-97 ◽  
Author(s):  
Chris A. Veale ◽  
James R. Jr. Damewood ◽  
Gary B. Steelman ◽  
Craig Bryant ◽  
Bruce Gomes ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Trifluoromethyl Ketones ◽  
Human Leukocyte Elastase ◽  
Peptidic Inhibitors

Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and x-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones

1995 ◽  
Vol 38 (1) ◽  
pp. 98-108 ◽  
Author(s):  
Chris A. Veale ◽  
Peter R. Bernstein ◽  
Craig Bryant ◽  
Christopher Ceccarelli ◽  
James R. Jr. Damewood ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
X Ray ◽  
X Ray Crystallography ◽  
Trifluoromethyl Ketones ◽  
Human Leukocyte Elastase ◽  
Orally Active

Nonpeptidic Inhibitors of Human Leukocyte Elastase. 2. Design, Synthesis, and in vitro Activity of a Series of 3-Amino-6-aryl-2-oxopyridyl Trifluoromethyl Ketones

1994 ◽  
Vol 37 (20) ◽  
pp. 3303-3312 ◽  
Author(s):  
James R. Damewood ◽  
Philip D. Edwards ◽  
Scott Feeney ◽  
Bruce C. Gomes ◽  
Gary B. Steelman ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Trifluoromethyl Ketones ◽  
Human Leukocyte Elastase

ChemInform Abstract: Design, Synthesis and Stability of N-Acyloxymethyl- and N-Aminocarbonyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 32 (33) ◽  
pp. no-no
Author(s):  
A. Clemente ◽  
A. Domingos ◽  
A. P. Grancho ◽  
J. Iley ◽  
R. Moreira ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

1995 ◽  
Vol 3 (4) ◽  
pp. 375-381 ◽  
Author(s):  
William C. Groutas ◽  
Michael J. Brubaker ◽  
Lee S. Chong ◽  
Radhika Venkataraman ◽  
He Huang ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Biological Evaluation ◽  
Cathepsin G ◽  
Proteinase 3 ◽  
Potential Mechanism ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase ◽  
Synthesis And Biological Evaluation
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