Design, Synthesis, and Binding Affinities of Potential Positron Emission Tomography (PET) Ligands for Visualization of Brain Dopamine D3Receptors

2006 ◽  
Vol 49 (1) ◽  
pp. 358-365 ◽  
Author(s):  
Marcello Leopoldo ◽  
Enza Lacivita ◽  
Paola De Giorgio ◽  
Nicola A. Colabufo ◽  
Mauro Niso ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Binding Affinities ◽  
Brain Dopamine ◽  
Design Synthesis ◽  
Positron Emission

Sight and Insight: Regional Cerebral Metabolic Activity in Schizophrenia Visualised by Positron Emission Tomography, and Competing Neurodevelopmental Perspectives

1990 ◽  
Vol 156 (5) ◽  
pp. 615-619 ◽  
Author(s):  
John L. Waddington
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Dopamine Receptors ◽  
Metabolic Activity ◽  
New Technology ◽  
Emission Tomography ◽  
Brain Dopamine ◽  
The Past ◽  
Positron Emission ◽  
Schizophrenic Patients

Over the past several years there has emerged a family of highly sophisticated but technically complex procedures for the visualisation of a range of cerebral functions in living man (Andreasen, 1988). The images they produce are so beguiling not just because of their potential to give new insights into the pathophysiology and treatment of major psychiatric disorders, but because they convey information through a quite fundamental modality: people are only convinced by what they can see. However, initial applications of such new technology have appeared just as likely to generate new questions and contradictions as to provide answers to current issues. This is readily illustrated by recent studies on the imaging of brain dopamine receptors in schizophrenic patients by positron emission tomography (PET) (see Waddington, 1989a).

Design, Synthesis, and Initial Evaluation of a High Affinity Positron Emission Tomography Probe for Imaging Matrix Metalloproteinases 2 and 9

2013 ◽  
Vol 56 (12) ◽  
pp. 4912-4920 ◽  
Author(s):  
Svetlana V. Selivanova ◽  
Timo Stellfeld ◽  
Tobias K. Heinrich ◽  
Adrienne Müller ◽  
Stefanie D. Krämer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Matrix Metalloproteinases ◽  
Initial Evaluation ◽  
Emission Tomography ◽  
Design Synthesis ◽  
High Affinity ◽  
Positron Emission
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