Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents:  Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates1

Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.04.035 ◽

2018 ◽

Vol 26 (9) ◽

pp. 2674-2685 ◽

Cited By ~ 3

Author(s):

Hao Li ◽

Fang Fang ◽

Yunqi Liu ◽

Liangmin Xue ◽

Meng Wang ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Dihydrofolate Reductase Inhibitors

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701052u ◽

2008 ◽

Vol 51 (1) ◽

pp. 68-76 ◽

Cited By ~ 30

Author(s):

Aleem Gangjee ◽

Wei Li ◽

Jie Yang ◽

Roy L. Kisliuk

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents

10.1016/j.ejmech.2019.06.013 ◽

2019 ◽

Vol 178 ◽

pp. 329-340

Author(s):

Tianfeng Gao ◽

Congying Zhang ◽

Xiaowei Shi ◽

Ran Guo ◽

Kai Zhang ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents

10.1016/j.ejmech.2016.03.032 ◽

2016 ◽

Vol 115 ◽

pp. 245-256 ◽

Cited By ~ 6

Author(s):

Yi Liu ◽

Meng Li ◽

Hongying Zhang ◽

Jiangsong Yuan ◽

Congying Zhang ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104995 ◽

2021 ◽

pp. 104995

Author(s):

Li-Qiang Wu ◽

Xin Ma ◽

Zhao-Peng Liu

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, synthesis and biological evaluation of novel EGFR/HER2 dual inhibitors bearing a oxazolo[4,5-g]quinazolin-2(1H)-one scaffold

10.1016/j.ejmech.2016.04.072 ◽

2016 ◽

Vol 120 ◽

pp. 26-36 ◽

Cited By ~ 17

Author(s):

Siyuan Yin ◽

Chunming Tang ◽

Bin Wang ◽

Ying Zhang ◽

Liliang Zhou ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.200029085 ◽

2010 ◽

Vol 31 (29) ◽

pp. no-no

Author(s):

Yi Xia ◽

Zheng-Yu Yang ◽

Peng Xia ◽

Kenneth F. Bastow ◽

Yuka Nakanishi ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, Synthesis, and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors1

Journal of Medicinal Chemistry ◽

10.1021/jm0306327 ◽

2004 ◽

Vol 47 (14) ◽

pp. 3689-3692 ◽

Cited By ~ 24

Author(s):

Aleem Gangjee ◽

Xin Lin ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, Synthesis and Biological Evaluation of Novel Phenylsulfonylurea Derivatives as PI3K/mTOR Dual Inhibitors

Molecules ◽

10.3390/molecules23071553 ◽

2018 ◽

Vol 23 (7) ◽

pp. 1553

Author(s):

Bingbing Zhao ◽

Fei Lei ◽

Caolin Wang ◽

Binliang Zhang ◽

Zunhua Yang ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents

10.1016/j.ejmech.2018.12.009 ◽

2019 ◽

Vol 163 ◽

pp. 690-709 ◽

Cited By ~ 19

Author(s):

Yunlei Hou ◽

Liangyu Zhu ◽

Zhiwei Li ◽

Qi Shen ◽

Qiaoling Xu ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽