One-Pot Synthesis of Diarylmethanones through Palladium-Catalyzed Sequential Coupling and Aerobic Oxidation of Aryl Bromides with Acetophenone as a Latent Carbonyl Donor

2014 ◽  
Vol 79 (14) ◽  
pp. 6554-6562 ◽  
Author(s):  
Xing Wang ◽  
Fu-Di Liu ◽  
Hai-Yang Tu ◽  
Ai-Dong Zhang
Keyword(s):  
Aerobic Oxidation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
Sequential Coupling

Improved Synthesis of Symmetrical 2,5-Diarylimidazoles by One-Pot Palladium-Catalyzed Direct Arylation Tailored on the Electronic Features of the Aryl Halide

Synthesis ◽  
2017 ◽  
Vol 49 (20) ◽  
pp. 4676-4686 ◽  
Author(s):  
Marco Lessi ◽  
Gianmarco Panzetta ◽  
Giulia Marianetti ◽  
Fabio Bellina
Keyword(s):  
Aryl Halide ◽  
One Pot ◽  
Direct Arylation ◽  
One Pot Synthesis ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
The One

Two methods for the one-pot synthesis of 2,5-diarylimidazoles by palladium-catalyzed direct C–H arylation of 1-substituted imidazoles with aryl bromides have been devised. The first method, promoted by copper(I) iodide, is best suited for electron-poor aryl bromides, and also allows the 2,5-diarylation of thiazole and oxazole. The use of xylene instead of DMA is the key for the efficiency of the second method, which gives the best results with electron-rich aryl bromides.

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