Tandem Michael Addition/Cyclization Reaction of 2,3-Allenoates with Organozincs: Facile Synthesis of Isocoumarins

2013 ◽  
Vol 15 (15) ◽  
pp. 3884-3887 ◽  
Author(s):  
Bo Chen ◽  
Shengming Ma
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
Facile Synthesis

Tandem Intermolecular–Intramolecular Michael Addition of Bifunctional Hetero Nucleophiles to Polyfluoro-2-alkynoic Acids. Facile Synthesis of Polyfluoroalkylated Azaheterocycles

1994 ◽  
Vol 67 (11) ◽  
pp. 3021-3029 ◽  
Author(s):  
Kazumasa Funabiki ◽  
Kazushige Tamura ◽  
Takashi Ishihara ◽  
Hiroki Yamanaka
Keyword(s):  
Michael Addition ◽  
Facile Synthesis

One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 141-146 ◽  
Author(s):  
Yun Shi ◽  
Jing Huang ◽  
Yan-Fang Yang ◽  
Lu-Yong Wu ◽  
Yan-Ning Niu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

ChemInform Abstract: Facile Synthesis of 3-sec-Alkyl Substituted 7-Azaindoles by Michael Addition of Carbon Nucleophiles to Vinylogous Imine Intermediates Generated in situ from 3-(1-Arylsulfonylalkyl)-7-azaindoles.

ChemInform ◽  
2015 ◽  
Vol 46 (31) ◽  
pp. no-no
Author(s):  
Gan Luo ◽  
Linhai Jing ◽  
Dabin Qin ◽  
Rongming Wang ◽  
Lunqiang Jin ◽  
...  
Keyword(s):  
Michael Addition ◽  
Facile Synthesis ◽  
Carbon Nucleophiles

Facile Synthesis of 2-Arylindoles through Plancher-Type Rearrangement of 3-Alkyl-3-Arylindolenines

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1994-1999
Author(s):  
Santhosh Chittimalla ◽  
Chennakesavulu Bandi ◽  
Vinod Gadi ◽  
Siva Gunturu
Keyword(s):  
Michael Addition ◽  
Facile Synthesis ◽  
Type C ◽  
High Yields

3-Alkylindoles on reaction with a cyclohexa-2,4-dien-1-one catalyzed by BF3·OEt2 gave the corresponding 3-alkyl-3-arylindolenines in high yields through a tandem Michael addition/aromatization sequence. In the presence of HCl, these indolenine derivatives underwent a facile Plancher-type C-3 to C-2 aryl rearrangement to deliver the corresponding 2-arylindoles.

Facile Synthesis of Indolines by a Tandem Nitro-reduction Aza Michael Addition Reaction

Heterocycles ◽  
2013 ◽  
Vol 87 (10) ◽  
pp. 2023 ◽  
Author(s):  
Jason Guy Taylor ◽  
Wellington Martins Ventura ◽  
Luiz Guilherme Souza de Assis
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Facile Synthesis ◽  
Nitro Reduction

Facile synthesis of novel 3,4,5-trisubstituted-1,2,4-triazin-6(1H)-onesviaa sequential Ugi–Smiles type/nucleophilic substitution/cyclization reaction

2018 ◽  
Vol 42 (21) ◽  
pp. 17533-17537
Author(s):  
Sorour Ramezanpour ◽  
Mohammad Nasim Rezaei ◽  
Aref Vaezghaemi ◽  
Frank Rominger
Keyword(s):  
Nucleophilic Substitution ◽  
Biological Activities ◽  
Cyclization Reaction ◽  
Facile Synthesis ◽  
Innovative Strategy ◽  
Pyrimidine Bases

An innovative strategy for synthesis of a library of complex multi-substituted 1,2,4-triazine-6-ones. These structures are analogues of pyrimidine bases with possible enhanced biological activities.

Facile Synthesis of Indolelactones Using Mn(III)-Based Oxidative Substitution-Cyclization Reaction

Heterocycles ◽  
2018 ◽  
Vol 97 (1) ◽  
pp. 431 ◽  
Author(s):  
Hiroshi Nishino ◽  
Takeshi Inoue
Keyword(s):  
Cyclization Reaction ◽  
Facile Synthesis ◽  
Oxidative Substitution

New Facile Synthesis of 3,4-Dihydroquinazoline-2(1H)-thiones by a Sequential Ugi-Azide/Staudinger/Aza-Wittig/Cyclization Reaction

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1053-1056 ◽  
Author(s):  
Jun Xiong ◽  
Qing Min ◽  
Gang Yao ◽  
Jia-An Zhang ◽  
Hai-Feng Yu ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Facile Synthesis ◽  
Trimethylsilyl Azide

A new facile synthesis of 3,4-dihydroquinazoline-2(1H)-thiones by an Ugi-azide/Staudinger/aza-Wittig/cyclization sequence has been developed. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced tetrazoles, which, when treated with methyldiphenylphosphane and CS2, produced 3,4-dihydroquinazoline-2(1H)-thiones in good overall yields via a sequential Staudinger/aza-Wittig/cyclization reaction.

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