Reliable Prediction of Complex Phenotypes from a Modular Design in Free Energy Space: An Extensive Exploration of thelacOperon

ACS Synthetic Biology ◽

10.1021/sb400013w ◽

2013 ◽

Vol 2 (10) ◽

pp. 576-586 ◽

Author(s):

Jose M. G. Vilar ◽

Leonor Saiz

Keyword(s):

Free Energy ◽

Modular Design ◽

Energy Space ◽

Reliable Prediction ◽

Complex Phenotypes

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Intelligent free energy usage through radiant energy space phenomenon: An IoT-powered prototype for modified Bedini generator

Microprocessors and Microsystems ◽

10.1016/j.micpro.2021.104319 ◽

2021 ◽

pp. 104319

Author(s):

Hina Inam ◽

Fadi Al-Turjman

Keyword(s):

Free Energy ◽

Radiant Energy ◽

Energy Space ◽

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Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field

Journal of the American Chemical Society ◽

10.1021/ja512751q ◽

2015 ◽

Vol 137 (7) ◽

pp. 2695-2703 ◽

Author(s):

Lingle Wang ◽

Yujie Wu ◽

Yuqing Deng ◽

Byungchan Kim ◽

Levi Pierce ◽

...

Keyword(s):

Free Energy ◽

Drug Discovery ◽

Ligand Binding ◽

Force Field ◽

Free Energy Calculation ◽

Energy Calculation ◽

Reliable Prediction

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Conformational transitions in potential and free energy space for furanoses and 2'-deoxynucleosides

Journal of the American Chemical Society ◽

10.1021/ja00063a045 ◽

1993 ◽

Vol 115 (10) ◽

pp. 4218-4227 ◽

Author(s):

Henry A. Gabb ◽

Stephen C. Harvey

Keyword(s):

Free Energy ◽

Conformational Transitions ◽

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Faculty Opinions recommendation of Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725328142.793512272 ◽

2015 ◽

Author(s):

Xiayang Qiu ◽

Ye Che

Keyword(s):

Free Energy ◽

Drug Discovery ◽

Ligand Binding ◽

Force Field ◽

Free Energy Calculation ◽

Energy Calculation ◽

Reliable Prediction

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Faculty Opinions recommendation of Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725328142.793509117 ◽

2015 ◽

Author(s):

Jürgen Bajorath

Keyword(s):

Free Energy ◽

Drug Discovery ◽

Ligand Binding ◽

Force Field ◽

Free Energy Calculation ◽

Energy Calculation ◽

Reliable Prediction

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Metadynamics As a Tool for Mapping the Conformational and Free-Energy Space of Peptides — The Alanine Dipeptide Case Study

The Journal of Physical Chemistry B ◽

10.1021/jp100950w ◽

2010 ◽

Vol 114 (16) ◽

pp. 5632-5642 ◽

Author(s):

Jiří Vymětal ◽

Jiří Vondrášek

Keyword(s):

Free Energy ◽

Energy Space ◽

Alanine Dipeptide

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Faculty Opinions recommendation of Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725328142.793526543 ◽

2016 ◽

Author(s):

Anandan Palani ◽

Xianhai Huang

Keyword(s):

Free Energy ◽

Drug Discovery ◽

Ligand Binding ◽

Force Field ◽

Free Energy Calculation ◽

Energy Calculation ◽

Reliable Prediction

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Faculty Opinions recommendation of Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725328142.793503553 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

Free Energy ◽

Drug Discovery ◽

Ligand Binding ◽

Force Field ◽

Free Energy Calculation ◽

Energy Calculation ◽

Reliable Prediction

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From A to B in free energy space

The Journal of Chemical Physics ◽

10.1063/1.2432340 ◽

2007 ◽

Vol 126 (5) ◽

pp. 054103 ◽

Author(s):

Davide Branduardi ◽

Francesco Luigi Gervasio ◽

Michele Parrinello

Keyword(s):

Free Energy ◽

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Encultured minds, not error reduction minds

Behavioral and Brain Sciences ◽

10.1017/s0140525x19002826 ◽

2020 ◽

Vol 43 ◽

Author(s):

Robert Mirski ◽

Mark H. Bickhard ◽

David Eck ◽

Arkadiusz Gut

Keyword(s):

Free Energy ◽

Error Reduction ◽

Energy Principle ◽

Free Energy Principle ◽

Current Article

Abstract There are serious theoretical problems with the free-energy principle model, which are shown in the current article. We discuss the proposed model's inability to account for culturally emergent normativities, and point out the foundational issues that we claim this inability stems from.

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