DNA Repair Synthesis in Mammalian Cells exposed to a Series of Oncogenic and Non-Oncogenic Derivatives of 4-Nitroquinoline 1-Oxide

Nature ◽  
1971 ◽  
Vol 229 (5284) ◽  
pp. 416-419 ◽  
Author(s):  
H. F. STICH ◽  
R. H. C. SAN ◽  
Y. KAWAZOE
Keyword(s):  
Dna Repair ◽  
Mammalian Cells ◽  
Repair Synthesis ◽  
Dna Repair Synthesis ◽  
Derivatives Of

Soluble and insoluble nickel compounds induce DNA repair synthesis in cultured mammalian cells☆

1983 ◽  
Vol 17 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Steven H. Robison ◽  
Orazio Cantoni ◽  
J.Daniel Heck ◽  
Max Costa
Keyword(s):  
Dna Repair ◽  
Mammalian Cells ◽  
Repair Synthesis ◽  
Nickel Compounds ◽  
Dna Repair Synthesis

Effect of split doses of N-methyl-N-nitrosourea on DNA repair synthesis in cultured mammalian cells

1977 ◽  
Vol 3 ◽  
pp. 183-188 ◽  
Author(s):  
Luciano Zardi ◽  
Leone St. Vincent ◽  
Alain Barbin ◽  
Ruggero Montesano ◽  
Geoffrey P. Margison
Keyword(s):  
Dna Repair ◽  
Mammalian Cells ◽  
Repair Synthesis ◽  
Dna Repair Synthesis

scholarly journals Long‐patch DNA repair synthesis during base excision repair in mammalian cells

EMBO Reports ◽  
2003 ◽  
Vol 4 (4) ◽  
pp. 363-367 ◽  
Author(s):  
Ulrike Sattler ◽  
Philippe Frit ◽  
Bernard Salles ◽  
Patrick Calsou
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Mammalian Cells ◽  
Excision Repair ◽  
Repair Synthesis ◽  
Base Excision ◽  
Dna Repair Synthesis

scholarly journals Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 ◽  
Vol 12 (5) ◽  
pp. 2109-2117 ◽  
Author(s):  
M. Molinete ◽  
W. Vermeulen ◽  
A. Bürkle ◽  
J. Ménissier-de Murcia ◽  
J.H. Küpper ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Binding ◽  
Mammalian Cells ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Repair Synthesis ◽  
Dna Repair Synthesis

scholarly journals Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

2021 ◽  
Vol 7 (24) ◽  
pp. eabf1771
Author(s):  
Gurushankar Chandramouly ◽  
Jiemin Zhao ◽  
Shane McDevitt ◽  
Timur Rusanov ◽  
Trung Hoang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Repair ◽  
Mammalian Cells ◽  
Dna Polymerases ◽  
Hydroxyl Groups ◽  
Dna Breaks ◽  
Repair Synthesis ◽  
Reverse Transcriptases ◽  
Dna Repair Synthesis ◽  
Multiple Hydrogen Bonds

Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides and promote RNA-templated DNA repair synthesis remains unknown. We find that human Polθ reverse transcribes RNA, similar to retroviral reverse transcriptases (RTs). Polθ exhibits a significantly higher velocity and fidelity of deoxyribonucleotide incorporation on RNA versus DNA. The 3.2-Å crystal structure of Polθ on a DNA/RNA primer-template with bound deoxyribonucleotide reveals that the enzyme undergoes a major structural transformation within the thumb subdomain to accommodate A-form DNA/RNA and forms multiple hydrogen bonds with template ribose 2′-hydroxyl groups like retroviral RTs. Last, we find that Polθ promotes RNA-templated DNA repair in mammalian cells. These findings suggest that Polθ was selected to accommodate template ribonucleotides during DNA repair.

scholarly journals Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion

1989 ◽  
Vol 264 (36) ◽  
pp. 21788-21792
Author(s):  
J Hansson ◽  
M Munn ◽  
W D Rupp ◽  
R Kahn ◽  
R D Wood
Keyword(s):  
Dna Repair ◽  
Human Cell ◽  
Repair Synthesis ◽  
Short Region ◽  
Cell Extracts ◽  
Dna Repair Synthesis

scholarly journals Enhanced DNA Repair Synthesis in Hyperacetylated Nucleosomes

1989 ◽  
Vol 264 (19) ◽  
pp. 11026-11034
Author(s):  
B Ramanathan ◽  
M J Smerdon
Keyword(s):  
Dna Repair ◽  
Repair Synthesis ◽  
Dna Repair Synthesis

DNA repair synthesis-related enzymes during spermatogenesis in the mouse

1984 ◽  
Vol 153 (2) ◽  
pp. 499-505 ◽  
Author(s):  
P. Orlando ◽  
P. Grippo ◽  
R. Geremia
Keyword(s):  
Dna Repair ◽  
Repair Synthesis ◽  
Dna Repair Synthesis
Sign in / Sign up

Export Citation Format

Share Document