Multiple innervation of cerebellar Purkinje cells by climbing fibres in staggerer mutant mouse

Nature ◽  
1980 ◽  
Vol 283 (5746) ◽  
pp. 483-484 ◽  
Author(s):  
F. Crepel ◽  
N. Delhaye-Bouchaud ◽  
J. M. Guastavino ◽  
I. Sampaio
Keyword(s):  
Purkinje Cells ◽  
Mutant Mouse ◽  
Climbing Fibres ◽  
Cerebellar Purkinje Cells

Excitation of Cerebellar Purkinje Cells by the Climbing Fibres

Nature ◽  
1964 ◽  
Vol 203 (4942) ◽  
pp. 245-246 ◽  
Author(s):  
JOHN ECCLES ◽  
R. LLINAS ◽  
K. SASAKI
Keyword(s):  
Purkinje Cells ◽  
Climbing Fibres ◽  
Cerebellar Purkinje Cells

Altered 9-O acetylation of disialogangliosides in cerebellar Purkinje cells of the nervous mutant mouse

1994 ◽  
Vol 662 (1-2) ◽  
pp. 223-232 ◽  
Author(s):  
Miyuki Yamamoto ◽  
Gerald A. Schwarting ◽  
James E. Crandall
Keyword(s):  
Purkinje Cells ◽  
Mutant Mouse ◽  
Cerebellar Purkinje Cells

scholarly journals Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells

2021 ◽  
Vol 15 ◽  
Author(s):  
Liansheng Chang ◽  
Shahid Hussain Soomro ◽  
Hongfeng Zhang ◽  
Hui Fu
Keyword(s):  
Motion Control ◽  
Purkinje Cells ◽  
Motor Function ◽  
Knockout Mice ◽  
Mutant Mouse ◽  
Cerebellar Purkinje Cells ◽  
Cerebellar Cells

Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult. This protein seems to play minor functions during development as Ankfy1 knockout mice appear normal till adult. However, at 9-month-old, knockout mice showed abnormal cerebellum with reduced vermis size and developed defective motor function. Further investigation demonstrated that the cerebellum of the mutant mouse has lost most of its Purkinje cells, while other cerebellar cells remained largely normal. Our data suggested that the Ankfy1 might be important for the maintenance of cerebellar Purkinje cells.

Abnormalities in cerebellar Purkinje cells in the novel ataxic mutant mouse, pogo

2000 ◽  
Vol 125 (1-2) ◽  
pp. 61-67 ◽  
Author(s):  
Young-Gil Jeong ◽  
Byung-Hwa Hyun ◽  
Richard Hawkes
Keyword(s):  
Purkinje Cells ◽  
Mutant Mouse ◽  
The Novel ◽  
Cerebellar Purkinje Cells
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