Lewis base mediated halogenation/semipinacol rearrangement of diazo compounds: new access to α-halo-quaternary ketones

2014 ◽  
Vol 50 (68) ◽  
pp. 9773-9775 ◽  
Author(s):  
Haibin Mao ◽  
Zhongkai Tang ◽  
Hongwen Hu ◽  
Yixiang Cheng ◽  
Wen-Hua Zheng ◽  
...  
Keyword(s):  
Lewis Base ◽  
Diazo Compounds ◽  
Semipinacol Rearrangement

A novel halogenation/semipinacol rearrangement of α-diazo alcohol catalyzed by Lewis base has been developed through a carbene-free mechanism.

ChemInform Abstract: Lewis Base Mediated Halogenation/Semipinacol Rearrangement of Diazo Compounds: New Access to α-Halo-quaternary Ketones.

ChemInform ◽  
2015 ◽  
Vol 46 (4) ◽  
pp. no-no
Author(s):  
Haibin Mao ◽  
Zhongkai Tang ◽  
Hongwen Hu ◽  
Yixiang Cheng ◽  
Wen-Hua Zheng ◽  
...  
Keyword(s):  
Lewis Base ◽  
Diazo Compounds ◽  
Semipinacol Rearrangement

Construction of Enantiomerically Enriched Diazo Compounds Using Diazo Esters as Nucleophiles: Chiral Lewis Base Catalysis

2013 ◽  
Vol 52 (24) ◽  
pp. 6288-6292 ◽  
Author(s):  
Haibin Mao ◽  
Aijun Lin ◽  
Yan Shi ◽  
Zhijie Mao ◽  
Xuebin Zhu ◽  
...  
Keyword(s):  
Lewis Base ◽  
Base Catalysis ◽  
Diazo Compounds ◽  
Diazo Esters

Lewis Base/Brønsted Acid Co‐catalyzed Enantioselective Sulfenylation/Semipinacol Rearrangement of Di‐ and Trisubstituted Allylic Alcohols

2019 ◽  
Vol 131 (36) ◽  
pp. 12621-12626 ◽  
Author(s):  
Yu‐Yang Xie ◽  
Zhi‐Min Chen ◽  
Hui‐Yun Luo ◽  
Hui Shao ◽  
Yong‐Qiang Tu ◽  
...  
Keyword(s):  
Lewis Base ◽  
Allylic Alcohols ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Semipinacol Rearrangement

Chiral Lewis Base Catalyzed Asymmetric Synthesis of Diazo Compounds

Synfacts ◽  
2013 ◽  
Vol 9 (07) ◽  
pp. 0788-0788
Keyword(s):  
Asymmetric Synthesis ◽  
Lewis Base ◽  
Diazo Compounds

Lewis Base/Brønsted Acid Co‐catalyzed Enantioselective Sulfenylation/Semipinacol Rearrangement of Di‐ and Trisubstituted Allylic Alcohols

2019 ◽  
Vol 58 (36) ◽  
pp. 12491-12496 ◽  
Author(s):  
Yu‐Yang Xie ◽  
Zhi‐Min Chen ◽  
Hui‐Yun Luo ◽  
Hui Shao ◽  
Yong‐Qiang Tu ◽  
...  
Keyword(s):  
Lewis Base ◽  
Allylic Alcohols ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Semipinacol Rearrangement

Construction of Enantiomerically Enriched Diazo Compounds Using Diazo Esters as Nucleophiles: Chiral Lewis Base Catalysis

2013 ◽  
Vol 125 (24) ◽  
pp. 6408-6412 ◽  
Author(s):  
Haibin Mao ◽  
Aijun Lin ◽  
Yan Shi ◽  
Zhijie Mao ◽  
Xuebin Zhu ◽  
...  
Keyword(s):  
Lewis Base ◽  
Base Catalysis ◽  
Diazo Compounds ◽  
Diazo Esters

ChemInform Abstract: Construction of Enantiomerically Enriched Diazo Compounds Using Diazo Esters as Nucleophiles: Chiral Lewis Base Catalysis.

ChemInform ◽  
2013 ◽  
Vol 44 (44) ◽  
pp. no-no
Author(s):  
Haibin Mao ◽  
Aijun Lin ◽  
Yan Shi ◽  
Zhijie Mao ◽  
Xuebin Zhu ◽  
...  
Keyword(s):  
Lewis Base ◽  
Base Catalysis ◽  
Diazo Compounds ◽  
Diazo Esters

Efficient and Stable Tin Perovskite Solar Cells by Introducing Π-conjugated Lewis Base

2019 ◽  
Author(s):  
Xiao Liu ◽  
Tianhao Wu ◽  
Liyuan Han
Keyword(s):  
Solar Cells ◽  
Perovskite Solar Cells ◽  
Lewis Base

Can the Lewis basicity of an isolated solvent molecule be used for characterizing solvent effects?

2020 ◽  
Vol 16 ◽  
Author(s):  
Jean-François Gal ◽  
Pierre-Charles Maria
Keyword(s):  
Solvent Effects ◽  
Molecular Level ◽  
Solvent Molecule ◽  
Lewis Base ◽  
Bulk Liquid ◽  
Donor Number ◽  
Special Focus ◽  
Solution Processes ◽  
Inert Solvent

Background: The ubiquitous Lewis acid/base interactions are important in solution processes. Analytical chemistry may benefit of a better understanding of the role of Lewis basicity, at the molecular level or acting through a bulk solvent effect. Objective: To clearly delineate (i) the basicity at a molecular level, hereafter referred as solute basicity, and (ii) the solvent basicity, which is a bulk-liquid property. Method: The literature that relates Lewis basicity scales and solvent effects is analyzed. A special focus is placed on two extensive scales, the Donor Number, DN, and the BF3 affinity scale, BF3A, which were obtained by calorimetric measurement on molecules as solutes diluted in a quasi-inert solvent, and therefore define a molecular Lewis basicity. We discuss the validity of these solute scales when regarded as solvent scales, in particular when the basicity of strongly associated liquids is discussed. Results: We demonstrate the drawbacks of confusing the Lewis basicity of a solvent molecule, isolated as solute, and that of the bulk liquid solvent itself. Conclusion: Consequently, we recommend a reasoned use of the concept of Lewis basicity taking clearly into account the specificity of the process for which a Lewis basicity effect may be invoked. In particular, the action of the Lewis base, either as an isolated entity, or as a bulk liquid, must be distinguished.

Metal-organic Nanopharmaceuticals

2020 ◽  
Vol 8 (3) ◽  
pp. 163-190
Author(s):  
Benjamin Steinborn ◽  
Ulrich Lächelt
Keyword(s):  
Metal Ions ◽  
Coordination Polymers ◽  
Active Agent ◽  
Lewis Base ◽  
High Loading ◽  
Active Components ◽  
Base Functions ◽  
Metal Organic ◽  
Theranostic Applications ◽  
Pharmacologically Active

: Coordinative interactions between multivalent metal ions and drug derivatives with Lewis base functions give rise to nanoscale coordination polymers (NCPs) as delivery systems. As the pharmacologically active agent constitutes a main building block of the nanomaterial, the resulting drug loadings are typically very high. By additionally selecting metal ions with favorable pharmacological or physicochemical properties, the obtained NCPs are predominantly composed of active components which serve individual purposes, such as pharmacotherapy, photosensitization, multimodal imaging, chemodynamic therapy or radiosensitization. By this approach, the assembly of drug molecules into NCPs modulates pharmacokinetics, combines pharmacological drug action with specific characteristics of metal components and provides a strategy to generate tailorable multifunctional nanoparticles. This article reviews different applications and recent examples of such highly functional nanopharmaceuticals with a high ‘material economy’. : Lay Summary: Nanoparticles, that are small enough to circulate in the bloodstream and can carry cargo molecules, such as drugs, imaging or contrast agents, are attractive materials for pharmaceutical applications. A high loading capacity is a generally aspired parameter of nanopharmaceuticals to minimize patient exposure to unnecessary nanomaterial. Pharmaceutical agents containing Lewis base functions in their molecular structure can directly be assembled into metal-organic nanopharmaceuticals by coordinative interaction with metal ions. Such coordination polymers generally feature extraordinarily high loading capacities and the flexibility to encapsulate different agents for a simultaneous delivery in combination therapy or ‘theranostic’ applications.

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