A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

2016 ◽  
Vol 52 (80) ◽  
pp. 11889-11892 ◽  
Author(s):  
Stacey E. Rudd ◽  
Peter Roselt ◽  
Carleen Cullinane ◽  
Rodney J. Hicks ◽  
Paul S. Donnelly
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
Mouse Models ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Ester Derivative ◽  
Desferrioxamine B ◽  
Positron Emission

A squaramide ester derivative of desferrioxamine B is used to attach zirconium-89 to the antibody trastuzumab and the new conjugate is used for positron emission tomography imaging in mouse models of breast cancer.

Positron-Emission Tomography Imaging of the TSPO with [18F]FEPPA in a Preclinical Breast Cancer Model

2013 ◽  
Vol 28 (3) ◽  
pp. 254-259 ◽  
Author(s):  
Neil Vasdev ◽  
David E. Green ◽  
Douglass C. Vines ◽  
Kristin McLarty ◽  
Patrick N. McCormick ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Cancer Model ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Breast Cancer Model
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