Alkylation of Quinoxalin-2(1H)-Ones Using Phosphonium Ylides as Alkylating Reagents

2021 ◽  
Author(s):  
Sha Peng ◽  
Jun-Jia Chen ◽  
Luo Yang
Keyword(s):  
Alkylating Reagents

A practical and efficient methodology for the construction of 3-alkylquinoxalinones through base promoted direct alkylation of quinoxalin-2(1H)-ones with phosphonium ylides as alkylating reagents under metal- and oxidant- free conditions was...

scholarly journals Dimethyl and Diethyl 2-Oxo-1,3-propanedisulfonates as Practical Alkylating Reagents

1983 ◽  
Vol 56 (4) ◽  
pp. 1257-1258 ◽  
Author(s):  
Fumio Ogura ◽  
Hachiro Yamaguchi ◽  
Tetsuo Otsubo ◽  
Takao Nakano ◽  
Takahiro Saito
Keyword(s):  
Alkylating Reagents

scholarly journals Frontispiece: Alkylating Reagents Employed in Catellani‐Type Reactions

2018 ◽  
Vol 24 (58) ◽  
Author(s):  
Ze‐Shui Liu ◽  
Qianwen Gao ◽  
Hong‐Gang Cheng ◽  
Qianghui Zhou
Keyword(s):  
Alkylating Reagents

Epoxides as Dual-Functionalized Alkylating Reagents in Catellani Reactions for the Assembly of Heterocycles

Synlett ◽  
2020 ◽  
Vol 31 (09) ◽  
pp. 829-837 ◽  
Author(s):  
Hong-Gang Cheng ◽  
Qianghui Zhou ◽  
Chenggui Wu
Keyword(s):  
Carboxylic Acid ◽  
Catalytic System ◽  
Potassium Salt ◽  
Salient Features ◽  
Alkylating Reagents ◽  
Straightforward Approach

Reported is a cooperative catalytic system consisting of a complex of Pd with dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (XPhos) and the potassium salt of 5-norbornene-2-carboxylic acid that permits the use of epoxides as dual-functionalized alkylating reagents in Catellani-type reactions for the assembly of heterocycles. Salient features of this research include readily available substrates, use of the potassium salt of 5-norbornene-2-carboxylic acid as a catalytic mediator as well as a base, and excellent regioselectivity for the cleavage of epoxides. This mild, chemoselective, scalable, atom- and step-economic protocol offers a straightforward approach for the assembly of isochroman and 2,3-dihydrobenzofuran scaffolds.

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