Polyacrylamide-gel-electrophoretic analysis of cultured skin fibroblasts from patients with Duchenne muscular dystrophy

1981 ◽  
Vol 9 (1) ◽  
pp. 118-119 ◽  
Author(s):  
ARTHUR H. M. BURGHES ◽  
MICHAEL J. DUNN ◽  
JAN A. WITKOWSKI ◽  
VICTOR DUBOWITZ
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Electrophoretic Analysis ◽  
Polyacrylamide Gel ◽  
Skin Fibroblasts ◽  
Cultured Skin

Abnormal Growth Kinetics and 5′-Nucleotidase Activities in Cultured Skin Fibroblasts from Patients with Duchenne Muscular Dystrophy

1981 ◽  
Vol 15 (11) ◽  
pp. 1411-1414 ◽  
Author(s):  
Sabina Liechti-Gallati ◽  
Hans Moser ◽  
Hans Peter Siegrist ◽  
Ulrich Wiesmann ◽  
Norbert N Herschkowitz
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Growth Kinetics ◽  
Skin Fibroblasts ◽  
Abnormal Growth ◽  
Cultured Skin

Proline incorporation by cultured skin fibroblasts from patients with Duchenne muscular dystrophy

1982 ◽  
Vol 57 (1) ◽  
pp. 41-54 ◽  
Author(s):  
R.G. Thompson ◽  
E.S. Sponder ◽  
E. Rosenmann ◽  
J.L. Hamerton ◽  
K. Wrogemann
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Skin Fibroblasts ◽  
Cultured Skin ◽  
Proline Incorporation

scholarly journals Letter to the Editor: Abnormal Growth Kinetics and 5′-Nucleotidase Activities in Cultured Skin Fibroblasts from Patients with Duchenne Muscular Dystrophy

1982 ◽  
Vol 16 (7) ◽  
pp. 588-588 ◽  
Author(s):  
Sabina Liechti-Gallati ◽  
Hans Moser ◽  
Hans Peter Siegrist ◽  
Ulrich Wiesmann ◽  
Norbert N Herschkowitz
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Growth Kinetics ◽  
Skin Fibroblasts ◽  
Abnormal Growth ◽  
Cultured Skin ◽  
Letter To The Editor

Biochemical investigations in cultured skin fibroblasts from patients with Duchenne muscular dystrophy

2008 ◽  
Vol 14 (1) ◽  
pp. 50-54 ◽  
Author(s):  
S. D. J. Pena ◽  
A. Vust ◽  
D. Tucker ◽  
J. L. Hamerton ◽  
K. Wrogemann
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Skin Fibroblasts ◽  
Cultured Skin

Electron Microscopy of Fibroblasts from Myotonic Muscular Dystrophy Patients

1981 ◽  
Vol 39 ◽  
pp. 498-499
Author(s):  
S. E. Miller ◽  
G. B. Hartwig ◽  
R. A. Nielsen ◽  
A. P. Frost ◽  
A. D. Roses
Keyword(s):  
Electron Microscopy ◽  
Muscular Dystrophy ◽  
Genetic Diseases ◽  
Skin Fibroblasts ◽  
Inborn Errors ◽  
Cytoplasmic Inclusions ◽  
Cultured Skin ◽  
Myotonic Muscular Dystrophy ◽  
Glycosaminoglycan Metabolism

Many genetic diseases can be demonstrated in skin cells cultured in vitro from patients with inborn errors of metabolism. Since myotonic muscular dystrophy (MMD) affects many organs other than muscle, it seems likely that this defect also might be expressed in fibroblasts. Detection of an alteration in cultured skin fibroblasts from patients would provide a valuable tool in the study of the disease as it would present a readily accessible and controllable system for examination. Furthermore, fibroblast expression would allow diagnosis of fetal and presumptomatic cases. An unusual staining pattern of MMD cultured skin fibroblasts as seen by light microscopy, namely, an increase in alcianophilia and metachromasia, has been reported; both these techniques suggest an altered glycosaminoglycan metabolism An altered growth pattern has also been described. One reference on cultured skin fibroblasts from a different dystrophy (Duchenne Muscular Dystrophy) reports increased cytoplasmic inclusions seen by electron microscopy. Also, ultrastructural alterations have been reported in muscle and thalamus biopsies from MMD patients, but no electron microscopical data is available on MMD cultured skin fibroblasts.

scholarly journals Cytotoxicity of lectins toward skin fibroblasts from patients with Duchenne muscular dystrophy and myotonic dystrophy

1986 ◽  
Vol 31 (2) ◽  
pp. 85-91 ◽  
Author(s):  
Kousaku Ohno ◽  
Chizuko Nakano ◽  
Shougo Ishii ◽  
Kenzo Takeshita
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Myotonic Dystrophy ◽  
Skin Fibroblasts
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