Clinical efficacy of highly purified, doubly virus-inactivated factor VIII/von Willebrand factor concentrate (FanhdiR) in the treatment of von Willebrand disease: a retrospective clinical study

Haemophilia ◽  
2002 ◽  
Vol 8 (6) ◽  
pp. 761-767 ◽  
Author(s):  
A. B. Federici ◽  
F. Baudo ◽  
C. Caracciolo ◽  
G. Mancuso ◽  
M. G. Mazzucconi ◽  
...  
Keyword(s):  
Clinical Study ◽  
Factor Viii ◽  
Clinical Efficacy ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Retrospective Clinical Study ◽  
Factor Concentrate ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Management of von Willebrand disease with a factor VIII‐poor von Willebrand factor concentrate: Results from a prospective observational post‐marketing study

2020 ◽  
Vol 18 (8) ◽  
pp. 1922-1933 ◽  
Author(s):  
Jenny Goudemand ◽  
Françoise Bridey ◽  
Ségolène Claeyssens ◽  
Nathalie Itzhar‐Baïkian ◽  
Annie Harroche ◽  
...  
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Post Marketing ◽  
Factor Concentrate ◽  
Von Willebrand ◽  
Willebrand Factor

Use of von Willebrand Factor Concentrate in Inherited von Willebrand Disease: How Often Is It Useful to Add Factor VIII?

2020 ◽  
Vol 34 (2) ◽  
pp. 128-129
Author(s):  
Nicolas Drillaud ◽  
Laurent Ardillon ◽  
Catherine Ternisien ◽  
Jean Baptiste Valentin ◽  
Marc Fouassier ◽  
...  
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Factor Concentrate ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Successful management of multiple pregnancies in a family with varying severity of Von Willebrand disease

2018 ◽  
Vol 11 (4) ◽  
pp. 192-194
Author(s):  
Patrick Harrington ◽  
Pippa Kyle ◽  
Jacky Cutler ◽  
Bella Madan
Keyword(s):  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
The Other ◽  
Severe Phenotype ◽  
Mild Phenotype ◽  
History Of ◽  
Specialist Treatment ◽  
Factor Concentrate ◽  
Von Willebrand ◽  
Willebrand Factor

We present the obstetric history of a family of three sisters with Von Willebrand disease, managed in our centre over the course of nine successful pregnancies. The abnormalities result from inheritance of an exon 50 skipping mutation in the Von Willebrand factor gene, resulting from consanguinity. Two of the sisters were identified as having a severe phenotype with a Von Willebrand factor level of less than 5 IU/dl, with the other having a mild phenotype. Of the sisters with a severe phenotype, one had a number of prenatal complications and required early onset prophylaxis with Von Willebrand factor concentrate, whilst the other had a less complicated clinical course, only requiring Von Willebrand factor concentrate to cover labour. The sister with mild Von Willebrand disease had a rise in Von Willebrand factor levels during pregnancy and required no specialist treatment. The report highlights the markedly different clinical courses that can occur in patients with Von Willebrand disease and the different approaches to management.

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