Plasma markers of coagulation activity in patients with mechanical heart valves on warfarin therapy

2000 ◽  
Vol 9 (3) ◽  
pp. A136
Author(s):  
J.E. Bray ◽  
E. Malan ◽  
T.E. Gan ◽  
R.E. Peverill
Keyword(s):  
Heart Valves ◽  
Warfarin Therapy ◽  
Mechanical Heart Valves ◽  
Coagulation Activity ◽  
Plasma Markers

scholarly journals Heartbeat: Warfarin therapy for mechanical heart valves

Heart ◽  
2017 ◽  
Vol 103 (3) ◽  
pp. 175-176
Author(s):  
Catherine M Otto
Keyword(s):  
Heart Valves ◽  
Warfarin Therapy ◽  
Mechanical Heart Valves

scholarly journals In-home Compared With In-Clinic Warfarin Therapy Monitoring in Mechanical Heart Valves: A Population-Based Study

2020 ◽  
Vol 4 (5) ◽  
pp. 511-520
Author(s):  
Martin van Zyl ◽  
Waldemar E. Wysokinski ◽  
Thomas M. Jaeger ◽  
Ana I. Casanegra ◽  
Bernard J. Gersh ◽  
...  
Keyword(s):  
Heart Valves ◽  
Warfarin Therapy ◽  
Therapy Monitoring ◽  
Population Based ◽  
Mechanical Heart Valves ◽  
Population Based Study

Khat Chewing Effect on the International Normalized Ratio in Patients with Mechanical Heart Valves under Warfarin Therapy

2020 ◽  
Vol 23 (11) ◽  
pp. 1487-1491
Author(s):  
Sultan Abdulwadou ◽  
Nouradden Noman Alja ◽  
Abdulwahab Omer Hussa ◽  
Khalid Mohammed A ◽  
Suliman Gafar Sali
Keyword(s):  
Heart Valves ◽  
Warfarin Therapy ◽  
International Normalized Ratio ◽  
Mechanical Heart Valves ◽  
Khat Chewing

scholarly journals Management of recurrent epistaxis in an anticoagulated patient by temporarily closing the nares with sutures

2008 ◽  
Vol 87 (4) ◽  
pp. 221-225
Author(s):  
Chee-Yean Eng ◽  
Teck-Aun Yew ◽  
Wai-Siene Ng ◽  
Amged S. El-Hawrani
Keyword(s):  
Heart Valves ◽  
Thromboembolic Event ◽  
Unusual Case ◽  
Warfarin Therapy ◽  
Anticoagulation Therapy ◽  
Medical Advice ◽  
Mechanical Heart Valves ◽  
Management Option ◽  
Recurrent Epistaxis ◽  
Anticoagulated Patient

We describe an unusual case of recurrent, refractory anterior epistaxis in an 86-year-old man with two mechanical heart valves who was on permanent warfarin therapy. His numerous episodes of epistaxis were incited by chronic nose-picking and strong nose-blowing, practices that he continued to engage in despite repeated medical advice to stop. Stopping his anticoagulation therapy was not considered as a management option because of an unacceptably high risk that this would lead to a thromboembolic event. Eventually, we temporarily sutured his nares closed, and his nosebleeds ceased. The suturing was performed in the ward with local anesthesia. This procedure was simple to perform, fairly well tolerated, easily reversible, and highly effective.

Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio

2019 ◽  
Vol 20 (9) ◽  
pp. 659-667 ◽  
Author(s):  
Jeong Yee ◽  
Woorim Kim ◽  
Byung Chul Chang ◽  
Jee Eun Chung ◽  
Kyung Eun Lee ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Bleeding Complication ◽  
Heart Valves ◽  
Warfarin Therapy ◽  
International Normalized Ratio ◽  
Mechanical Heart Valves ◽  
Bleeding Complications ◽  
Wild Type ◽  
Vegfa Gene

Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.

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