A method for computing low-frequency normal modes of large symmetric assemblies of macromolecules : Application to the disk of tobacco mosaic virus protein

1991 ◽  
Vol 88 ◽  
pp. 2726-2726
Author(s):  
T Simonson ◽  
D Perahia
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Normal Modes ◽  
Low Frequency ◽  
Virus Protein

Three-dimensional reconstruction of the stacked-disk aggregate of tobacco mosaic virus protein from electron micrographs

1971 ◽  
Vol 261 (837) ◽  
pp. 211-219 ◽  
Keyword(s):  
Electron Microscope ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Virus Protein ◽  
Protein Subunits ◽  
Microscope Images ◽  
Dimensional Reconstruction ◽  
Inner Parts

The three-dimensional structure of the stacked-disk rod of tobacco mosaic virus protein has been reconstructed to a resolution of about 2 nm from electron microscope images. Closed rings of seventeen protein subunits (compared with 16 ⅓ in one turn of the virus helix) are stacked in polar fashion, the stacking being accompanied by an axial perturbation of periodicity 5.3 nm connecting successive pairs of rings into disks. The axial perturbation consists of a movement towards each other of the outer parts of the subunits in the two rings comprising a disk, together with a movement of the inner parts in the opposite direction. This could be explained either by a bending of parts of the subunits in the appropriate directions or by a bodily tilting of the subunits in the two rings in opposite directions.

In vitro and in vivo aggregation of the defective PM2 tobacco mosaic virus protein

1966 ◽  
Vol 19 (1) ◽  
pp. 140-IN8 ◽  
Author(s):  
Albert Siegel ◽  
G.J. Hills ◽  
Roy Markham
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Virus Protein
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