An Unusual and Fatal Case of Cryptococcal Infection in a Renal Transplant Recipient

2017 ◽  
Vol 69 (4) ◽  
pp. A19
2011 ◽  
Vol 12 (2) ◽  
pp. 163-165
Author(s):  
Tânia Mara L.B. Araújo ◽  
Geraldo B. Silva Junior ◽  
Orivaldo A. Barbosa ◽  
Rafael S.A. Lima ◽  
Elizabeth F. Daher

Histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum.. The disseminated form is usually found in immunocompromised patients. A 53 year-old man, renal transplant recipient, was admitted with fever, dyspnea, productive cough, adynamia and weight loss. He was septic, but hemodynamically stable. The tracheal aspirate found intracellular fungi and the peripheral blood exam was compatible with histoplasmosis. The patient presented a progressive worsening of respiratory pattern and needed mechanical ventilation, vasoactive drugs and hemodialysis. A large spectrum antimicrobial therapy was started, including amphotericin B, but the patient died. Keyword: Disseminated histoplasmosis. Kidney transplantation. Immunosuppression DOI: http://dx.doi.org/10.3329/jom.v12i2.7125 JOM 2011; 12(2): 163-165


2013 ◽  
Vol 7 (01) ◽  
pp. 060-063 ◽  
Author(s):  
Ramachandraiah Chaya ◽  
Srinivasan Padmanabhan ◽  
Venugopal Anandaswamy ◽  
Aumir Moin

Cellulitis is an unusual presentation of cryptococcal infection in renal allograft recipients. In such patients, disseminated cryptococcal infection can result in significant morbidity and mortality. Patients are often treated with antibiotics before a definitive diagnosis is made, delaying appropriate therapy. We describe the case of a 43-year-old post renal transplant recipient presenting with fever and swelling in the right thigh. On physical examination, the patient was found to have features suggestive of cellulitis with minimal slurring of speech. Material obtained from incision and drainage of the wound showed yeast cells resembling Cryptococcus spp. Blood culture and cerebrospinal fluid culture were also found to have growth of Cryptococcus neoformans. He received treatment with amphotericin B 6 mg/kg daily intravenously for two weeks, then continued with fluconazole 400 mg daily for three months. The patient showed a remarkable improvement. There was no recurrence of cryptococcosis after four months of follow-up. The diagnosis of disseminated cryptococcosis should be considered in differential diagnosis of cellulitis among non HIV immunocompromised hosts. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively.


2017 ◽  
Vol 19 (4) ◽  
pp. e12704 ◽  
Author(s):  
Elie Helou ◽  
Matthew Grant ◽  
Marie Landry ◽  
Xinyu Wu ◽  
Jon S. Morrow ◽  
...  

2009 ◽  
Vol 11 (1) ◽  
pp. 68-71 ◽  
Author(s):  
J. Orsini ◽  
J. Nowakowski ◽  
V. Delaney ◽  
G. Sakoulas ◽  
G.P. Wormser

Nephrology ◽  
2005 ◽  
Vol 10 (6) ◽  
pp. 619-622 ◽  
Author(s):  
YUI-PONG SIU ◽  
KAY-TAI LEUNG ◽  
MATTHEW KA-HANG TONG ◽  
YUK-LUNG KWOK ◽  
PIK-KEI WONG ◽  
...  

1999 ◽  
Vol 37 (11) ◽  
pp. 3751-3755 ◽  
Author(s):  
Josep Guarro ◽  
María Isabel Antolín-Ayala ◽  
Josepa Gené ◽  
Jesús Gutiérrez-Calzada ◽  
Carlos Nieves-Díez ◽  
...  

We describe the second known case of human infection byTrichoderma harzianum. A disseminated fungal infection was detected in the postmortem examination of a renal transplant recipient and confirmed in culture. The only other reported infection by this fungus caused peritonitis in a diabetic patient. The in vitro antifungal susceptibilities of the clinical strain and three other strains of Trichoderma species to six antifungal drugs are provided. This case illustrates the widening spectrum of opportunisticTrichoderma spp. in immunocompromised patients and emphasizes the problems in diagnosing invasive fungal diseases.


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