The Next Generation of Antibody Drug Conjugates

2014 ◽  
Vol 41 (5) ◽  
pp. 637-652 ◽  
Author(s):  
Fiona Mack ◽  
Michael Ritchie ◽  
Puja Sapra
Keyword(s):  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Abstract 756: Development of next-generation antibody-drug conjugates for resistant HER2-positive tumors

2018 ◽  
Author(s):  
Vincent Lacasse ◽  
Jeffrey V. Leyton ◽  
Simon Beaudoin ◽  
Mark Barok ◽  
Heikki Joensuu
Keyword(s):  
Next Generation ◽  
Her2 Positive ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Emerging formats for next-generation antibody drug conjugates

2015 ◽  
Vol 10 (5) ◽  
pp. 463-481 ◽  
Author(s):  
Mahendra P Deonarain ◽  
Gokhan Yahioglu ◽  
Ioanna Stamati ◽  
Jared Marklew
Keyword(s):  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Development of dual-cleavage linkers for next generation antibody-drug conjugates with expanded therapeutic window

2020 ◽  
Author(s):  
Yun Kim ◽  
Ogunkoya Ayodele ◽  
Colin Hickle ◽  
Fangjiu Zhang ◽  
Chuprakov Stepan ◽  
...  
Keyword(s):  
Therapeutic Window ◽  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

2014 ◽  
Vol 12 (37) ◽  
pp. 7261-7269 ◽  
Author(s):  
Felix F. Schumacher ◽  
João P. M. Nunes ◽  
Antoine Maruani ◽  
Vijay Chudasama ◽  
Mark E. B. Smith ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Disulfide Bonds ◽  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Controlled Assembly ◽  
Drug Conjugates ◽  
Antibody Drug

Highly homogeneous ADCs are generated by the efficient bridging of interchain disulfide bonds in trastuzumab, using next generation maleimides.

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