Next Generation
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Aditi Naik

Abstract: Our need for higher performance and improved efficiency has led to the invention of 4G from 1G. This tendency to never settle has now brought us to a new generation of mobile communication - 5G. It is expected to provide more than just a faster network. Reduced latency, enormous netwrok capacity, greater reliability and overall improved user experience. This has come into focus with the possibility that the unused spectrum - (300 MHz to 30 GHz) can also be brought into use in the telecommunication inductry. As we know, everything comes with its own demerits and in this review paper, we shall discuss the health effects that microwave radiation has on living organisms with the antennas and connected devices being in close proximity to users and other organisms. Thereafter, we shall discuss the challenges and opportunities of the same. Keywords: next generation network, millimeter waves, health impact, tissue heating, radiation

2021 ◽  
Vol 60 ◽  
pp. 102520
Junneng Wen ◽  
Kent Rapp ◽  
Lukas R. Dahlin ◽  
Chien-Ting Li ◽  
Jacob Sebesta ◽  

2021 ◽  
Martin Kronbichler ◽  
Niklas Fehn ◽  
Peter Munch ◽  
Maximilian Bergbauer ◽  
Karl-Robert Wichmann ◽  

2021 ◽  
Vol 27 (11) ◽  
pp. 2948-2950
Lulan Wang ◽  
Dakai Liu ◽  
Lok Yung ◽  
George David Rodriguez ◽  
Nishant Prasad ◽  

2021 ◽  
pp. 1-7
Charles A. Gusho ◽  
Mia C. Weiss ◽  
Linus Lee ◽  
Steven Gitelis ◽  
Alan T. Blank ◽  

HLA ◽  
2021 ◽  
Orane Calvo De Olmos ◽  
Francoise Bonneville ◽  
Gaelle Blanchet ◽  
Alexandre Walencik

2021 ◽  
Vol 8 ◽  
Xiao-guang Cao ◽  
Chuang-wei Yu ◽  
Shu-sheng Zhou ◽  
Yu Huang ◽  
Chun-yan Wang

Background: Fungal infections of the central nervous system (CNS) are not commonly seen clinically. Clinical diagnosis of fungal infections often depend on the pathogen culture and the clinical features. This method is time-consuming and insensitive, which can lead to misdiagnosis. The authors introduce an adult patient with fungal infections diagnosed by next-generation sequencing (NGS).Case: The patient was a 60-year-old male Chinese who had both hypermyotonia of the lower extremities and fever. The auxiliary examinations such as MRI, CT, and cerebrospinal fluid (CSF) analysis showed obvious abnormalities. Because of the difficulties in diagnosis, it was hard to determine the treatment plan. The NGS detected specific sequences of Candida albicans in 3 days. The patient was then treated with liposomal amphotericin B and fluconazole. About 3 weeks later, the symptoms of the patient improved significantly and he was discharged from the hospital.Conclusion: Compared with the routine cultural method, NGS has made a huge advancement in infection diagnosis and targeting antimicrobial therapy for CNS infection.

2021 ◽  
Vol 7 (1) ◽  
Yan Liang ◽  
Chao Qian ◽  
Yinghong Xie ◽  
Xiang Huang ◽  
Junjie Chen ◽  

AbstractBreast cancer is the most common cancer worldwide. JWA is a microtubule-associated protein that has been identified as a tumor suppressor, and its downregulation in tumors is an independent adverse prognostic factor. The objective of this study was to explore the expression, regulation, and mechanism of JWA in trastuzumab-resistant breast cancers. In this study, we found that JWA expression was lower in trastuzumab-resistant breast cancers than that in trastuzumab-sensitive breast cancers. Furthermore, it was confirmed that overexpression of JWA inhibited proliferation and promoted apoptosis in trastuzumab-resistant breast cancers both in vitro and in vivo. In addition, the low expression of JWA in trastuzumab-resistant breast cancers is associated with a poor prognosis. Combining RNA-sequence datasets and next-generation sequencing, it was found that JWA negatively regulated CDK12, and was involved in the G1-to-S transition of the cell cycle. It has been reported that CDK12 drives breast cancer initiation and induces trastuzumab resistance. Taken together, high expression of JWA could inhibit the growth of trastuzumab-resistant breast cancer, and JWA is a potential predictive marker for trastuzumab resistance. In addition, targeted therapy with JWA may be a novel therapeutic strategy to improve the survival rate of trastuzumab-resistant breast cancer.

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