Asymmetric Synthesis of Fused Tetrahydroquinolines via Intramolecular Aza-Diels-Alder Reaction of ortho-Quinone Methide Imines
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Aza-Diels Alder reactions are straightforward processes in the construction of N-heterocycles, featuring inherent atom-economy and stereospecificity. Intramolecular strategies allow formation of bicyclic core structures with up to three stereocenters within a single step. Herein, this concept is combined with the chemistry of chiral Brønsted acid-bound ortho-quinone methide imines generating a range of interesting fused tetrahydro-quinolines in a diastereo- and enantioselective manner.
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2012 ◽
Vol 8
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pp. 1819-1824
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2005 ◽
Vol 46
(37)
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pp. 6355-6358
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2006 ◽
Vol 128
(40)
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pp. 13070-13071
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2006 ◽
Vol 45
(29)
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pp. 4796-4798
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2016 ◽
Vol 138
(35)
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pp. 11353-11359
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