Diversity-Oriented Synthesis of Biaryl Derivatives Using Cross-Enyne Metathesis, Diels-Alder Reaction, and Suzuki-Miyaura Cross-Coupling as Key Steps

Synlett ◽  
2011 ◽  
Vol 2011 (16) ◽  
pp. 2329-2334 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Vittal Seema
Keyword(s):  
Cross Coupling ◽  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diversity Oriented Synthesis ◽  
Diels Alder Reaction ◽  
Key Steps

scholarly journals Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

2018 ◽  
Vol 14 ◽  
pp. 2468-2481 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Milind Meshram ◽  
Chandravathi Chakkapalli
Keyword(s):  
Recent Work ◽  
Claisen Rearrangement ◽  
Cross Coupling ◽  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Cross Metathesis ◽  
Diels Alder Reaction ◽  
Synergistic Approach ◽  
Key Steps

This account provides an overview of recent work, including our own contribution dealing with Suzuki–Miyaura cross coupling in combination with metathesis (or vice-versa). Several cyclophanes, polycycles, macrocycles, spirocycles, stilbenes, biaryls, and heterocycles have been synthesized by employing a combination of Suzuki cross-coupling and metathesis. Various popular reactions such as Diels–Alder reaction, Claisen rearrangement, cross-metathesis, and cross-enyne metathesis are used. The synergistic combination of these powerful reactions is found to be useful for the construction of complex targets and fulfill synthetic brevity.

Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps

2012 ◽  
Vol 2012 (9) ◽  
pp. 1843-1850 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Deepti Goyal née Bansal ◽  
Niranjan Thota ◽  
Venu Srinivas
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps

scholarly journals Diversity-Oriented Approaches to Polycycles and Heterocycles via Enyne Metathesis and Diels–Alder Reaction as Key Steps

ACS Omega ◽  
2019 ◽  
Vol 4 (27) ◽  
pp. 22261-22273 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Arjun S. Chavan ◽  
Deepti Goyal
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps

ChemInform Abstract: Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps.

ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Sambasivarao Kotha ◽  
Deepti Goyal ◽  
Niranjan Thota ◽  
Venu Srinivas
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps

scholarly journals Diversity-oriented synthesis of 17-spirosteroids

2020 ◽  
Vol 16 ◽  
pp. 880-887
Author(s):  
Benjamin Laroche ◽  
Thomas Bouvarel ◽  
Martin Louis-Sylvestre ◽  
Bastien Nay
Keyword(s):  
Alder Reaction ◽  
Propargyl Alcohol ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Diels Alder Reaction ◽  
Microwave Irradiations ◽  
Classical Strategy ◽  
Alcohol Moiety

A diversity-oriented synthesis (DOS) approach has been used to functionalize 17-ethynyl-17-hydroxysteroids through a one-pot procedure involving a ring-closing enyne metathesis (RCEYM) and a Diels–Alder reaction on the resulting diene, under microwave irradiations. Taking advantage of the propargyl alcohol moiety present on commercially available steroids, this classical strategy was applied to mestranol and lynestrenol, giving a collection of new complex 17-spirosteroids.

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