Extrathoracic Arteriosclerotic Vascular Changes Preclude the Use of the Internal Thoracic Artery for Coronary Artery Bypass Grafting

AbstractCoronary artery disease (CAD) is one of the leading causes of mortality in the world. The most advanced forms of CAD are usually treated by means of coronary artery bypass grafting (CABG). The selection of the appropriate vessels as aortocoronary conduits is of paramount importance. The internal thoracic artery (ITA) or the great saphenous vein (SV) are often harvested. Furthermore, epigenetic processes have been recently associated with atherosclerosis, hypertension, and heart failure, and post-translational histone processes may play a key role in understanding the genetic predisposition of vessels to vascular diseases.In the experiment performed, the transcript levels of JHDM1D, PHF8, and HDAC 1-3 in SV and ITA used for CABG procedures with RT-qPCR were examined. Total RNA was isolated by the method of Chomczyński and Sachi. RNA samples were reverse transcribed into cDNA using a commercial kit. The determination of the level of the transcripts of the mentioned genes was performed using the Light Cycler® 96 Real-Time PCR kit. Our analyzes confirmed that the studied genes related to post-translational modifications of histones are expressed in SV and ITA. In the saphenous vein, the expression of each of the individual genes was higher. The most considerable difference in transcript levels was recorded for HDAC1 and the smallest difference in expression for HDAC2.Our research suggests that more processes related to histone demethylation and acetylation occur in the saphenous vein, which may affect the selection of a vessel for CABG, but this research requires more research and additional analysis.Running title: Histone regulating gene expression in common coronary artery bypass graft vessels

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Coronary Artery Bypass Grafting for Patients in Whom Preoperative Angiography Determined That the In Situ Left Internal Thoracic Artery Could Not Be Used.

Japanese Journal of Cardiovascular Surgery ◽

10.4326/jjcvs.31.331 ◽

2002 ◽

Vol 31 (5) ◽

pp. 331-336

Author(s):

Satoshi Yamashiro ◽

Yukio Kuniyoshi ◽

Kazufumi Miyagi ◽

Mitsuyoshi Shimoji ◽

Toru Uezu ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Internal Thoracic Artery ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting ◽

Left Internal Thoracic Artery

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Was the internal thoracic arterial graft selection for coronary artery bypass grafting appropriate in a patient with neurofibromatosis-1?

SAGE Open Medical Case Reports ◽

10.1177/2050313x18818724 ◽

2019 ◽

Vol 7 ◽

pp. 2050313X1881872

Author(s):

Taisuke Nakayama ◽

Mayuko Nakayama ◽

Takashi Harada ◽

Shingo Isshiki ◽

Hideki Sasaki ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Internal Thoracic Artery ◽

Artery Bypass ◽

Neurofibromatosis Type ◽

Bypass Grafting ◽

Artery Bypass Grafting ◽

Left Internal Thoracic Artery

Neurofibromatosis type 1, also called von Recklinghausen’s disease, is a hereditary congenital disorder that affects tissues of neuroectodermal or mesodermal origin. This disease has various manifestations, including pigmented skin lesions, cutaneous neurofibromas, skeletal abnormalities, and tumors of the central/peripheral nervous and gastrointestinal systems, and vascular abnormalities. Because of vasculopathy, part of the vessel wall may be replaced by neurofibromatosis tissue. Involvement of the internal thoracic artery is, however, extremely rare. Off-pump coronary artery bypass grafting using the left internal thoracic artery was performed for coronary arterial disease in a patient with neurofibromatosis, and the residual left internal thoracic artery vessel pathology was investigated. The left internal thoracic artery vessel showed intimal proliferation, medial thinning, and fragmentation of elastic tissue. However, these findings were not typical for von Recklinghausen’s neurofibromatosis. Internal thoracic artery graft selection was feasible for coronary artery bypass grafting in a patient with neurofibromatosis type 1.

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