The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain

Journal of Biological Chemistry ◽

10.1074/jbc.m117.799114 ◽

2017 ◽

Vol 292 (43) ◽

pp. 17777-17793 ◽

Author(s):

Zhen Xu ◽

Lokesh Gakhar ◽

Fletcher E. Bain ◽

Maria Spies ◽

Ernesto J. Fuentes

Keyword(s):

Coiled Coil ◽

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Pleckstrin Homology ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor ◽

Extension Domain

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Pleckstrin Homology Domain-mediated Activation of the Rho-specific Guanine Nucleotide Exchange Factor Dbs by Rac1

Journal of Biological Chemistry ◽

10.1074/jbc.m313099200 ◽

2003 ◽

Vol 279 (13) ◽

pp. 12786-12793 ◽

Author(s):

Li Cheng ◽

Gwendolyn M. Mahon ◽

Elena V. Kostenko ◽

Ian P. Whitehead

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Pleckstrin Homology Domain ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Pleckstrin Homology ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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RalGEF2, a Pleckstrin Homology Domain Containing Guanine Nucleotide Exchange Factor for Ral

Journal of Biological Chemistry ◽

10.1074/jbc.m001160200 ◽

2000 ◽

Vol 275 (38) ◽

pp. 29761-29766 ◽

Author(s):

Kim M. T. de Bruyn ◽

Johan de Rooij ◽

Rob M. F. Wolthuis ◽

Holger Rehmann ◽

Joep Wesenbeek ◽

...

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Pleckstrin Homology Domain ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Pleckstrin Homology ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Coiled-Coil Domain Containing Protein 124 Is a Novel Centrosome and Midbody Protein That Interacts with the Ras-Guanine Nucleotide Exchange Factor 1B and Is Involved in Cytokinesis

PLoS ONE ◽

10.1371/journal.pone.0069289 ◽

2013 ◽

Vol 8 (7) ◽

pp. e69289 ◽

Author(s):

Pelin Telkoparan ◽

Serap Erkek ◽

Elif Yaman ◽

Hani Alotaibi ◽

Defne Bayık ◽

...

Keyword(s):

Coiled Coil ◽

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Coiled Coil Domain ◽

Nucleotide Exchange Factor

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Substrate Specificity and Recognition Is Conferred by the Pleckstrin Homology Domain of the Dbl Family Guanine Nucleotide Exchange Factor P-Rex2

Journal of Biological Chemistry ◽

10.1074/jbc.m412495200 ◽

2005 ◽

Vol 280 (30) ◽

pp. 27508-27512 ◽

Author(s):

Raji E. Joseph ◽

F. A. Norris

Keyword(s):

Substrate Specificity ◽

Guanine Nucleotide Exchange Factor ◽

Pleckstrin Homology Domain ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Pleckstrin Homology ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Faculty Opinions recommendation of A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004087.46755 ◽

2002 ◽

Author(s):

Emmanuelle Caron

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Faculty Opinions recommendation of Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006014.72106 ◽

2002 ◽

Author(s):

Sean Munro

Keyword(s):

Brefeldin A ◽

Adaptor Protein ◽

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor ◽

Membrane Tubulation ◽

Adp Ribosylation Factor

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Faculty Opinions recommendation of P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1005684.103507 ◽

2002 ◽

Author(s):

Yoshimi Takai

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Faculty Opinions recommendation of Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009246.182473 ◽

2003 ◽

Author(s):

Catherine Jackson

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Secretory Vesicles ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Faculty Opinions recommendation of Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1011169.177910 ◽

2003 ◽

Author(s):

T Kendall Harden

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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Faculty Opinions recommendation of Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017285.202483 ◽

2004 ◽

Author(s):

Anne-Catherine Dock-Bregeon

Keyword(s):

Guanine Nucleotide Exchange Factor ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Exchange Factor ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factor

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