Sequence variants in exons of the BMP-15 gene in Chinese patients with premature ovarian failure

2007 ◽  
Vol 86 (5) ◽  
pp. 585-589 ◽  
Author(s):  
Peng Zhang ◽  
Yu-Hua Shi ◽  
Lai-Cheng Wang ◽  
Zi-Jiang Chen
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients ◽  
Sequence Variants

Mutation analysis ofFOXL2gene in Chinese patients with premature ovarian failure

2010 ◽  
Vol 26 (4) ◽  
pp. 246-249 ◽  
Author(s):  
Feng Ni ◽  
Qiaolian Wen ◽  
Binbin Wang ◽  
Sirui Zhou ◽  
Jing Wang ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients

scholarly journals New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients

2011 ◽  
Vol 22 (3) ◽  
pp. 312-316 ◽  
Author(s):  
Jing Wang ◽  
Binbin Wang ◽  
Junjie Song ◽  
Peisu Suo ◽  
Feng Ni ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients

scholarly journals Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure

2006 ◽  
Vol 154 (5) ◽  
pp. 739-744 ◽  
Author(s):  
Paul Laissue ◽  
Sophie Christin-Maitre ◽  
Philippe Touraine ◽  
Frederique Kuttenn ◽  
Olli Ritvos ◽  
...  
Keyword(s):  
Animal Models ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Sequence Variants ◽  
Vertebrate Species ◽  
Ovarian Insufficiency ◽  
Menstrual Cycles ◽  
Growth Differentiation Factor 9 ◽  
Pathogenic Effects ◽  
Control Samples

Background and objective: Mutations in bone morphogenic protein 15 (BMP15) and growth/differentiation factor 9 (GDF9) lead to altered fertility in animal models. In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF). Subject and methods: We have directly sequenced both genes in a cohort of 203 POF patients presenting with primary or secondary amenorrhea and high FSH levels and in a control population including 54 women with regular menstrual cycles who had at least one child. Results: We have identified several heterozygous variants. One alteration in GDF9 (S186Y) and one in BMP15 (L148P) may have pathogenic effects as both positions are conserved in vertebrate species, ranging from the chicken to mammals. These variants were absent in the control samples. We also found synonymous and neutral substitutions. Conclusions: We propose that although mutations in BMP15 and GDF9 are not a major cause of ovarian insufficiency, they may be involved in POF.

scholarly journals The screening of HELQ gene in Chinese patients with premature ovarian failure

2015 ◽  
Vol 31 (4) ◽  
pp. 573-576 ◽  
Author(s):  
Wenting Wang ◽  
Shidou Zhao ◽  
Lili Zhuang ◽  
Weiping Li ◽  
Yingying Qin ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients

MicroRNA-22-3p is down-regulated in the plasma of Han Chinese patients with premature ovarian failure

2015 ◽  
Vol 103 (3) ◽  
pp. 802-807.e1 ◽  
Author(s):  
Yujie Dang ◽  
Shidou Zhao ◽  
Yingying Qin ◽  
Ting Han ◽  
Weiping Li ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Han Chinese ◽  
Chinese Patients

Mutation analysis of FOXL2 gene in Chinese patients with premature ovarian failure

2009 ◽  
pp. 1-4
Author(s):  
Feng Ni ◽  
Qiaolian Wen ◽  
Binbin Wang ◽  
Sirui Zhou ◽  
Jing Wang ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients ◽  
Foxl2 Gene

scholarly journals Variation analysis of EXO1 gene in Chinese patients with premature ovarian failure

2016 ◽  
Vol 32 (3) ◽  
pp. 329-333
Author(s):  
Shizhen Su ◽  
Ting Han ◽  
Bowen Ma ◽  
Weiping Li ◽  
Yingying Qin ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Chinese Patients ◽  
Variation Analysis
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