The Effect of Beta-Adrenergic Blockade upon Gastric Acid Secretion and Gastrin Secretion during Hypoglycaemia before and after Vagotomy

We evaluated the effect of two beta-adrenergic agonists, isoproterenol (nonselective agonist) and terbutaline (selective beta 2-agonist), on gastric acid secretion stimulated by intravenous pentagastrin, bethanechol, or histamine in dogs with gastric fistulas. Intravenous infusion of isoproterenol or terbutaline inhibited pentagastrin-stimulated acid secretion to a significantly greater extent than they inhibited bethanechol- or histamine-stimulated acid secretion. For example, isoproterenol (12 micrograms X kg-1 X h-1) reduced mean pentagastrin-, bethanechol-, and histamine-stimulated acid output by 86, 63, and 14%, respectively. Percent inhibition of acid secretion with terbutaline (30 micrograms X kg-1 X h-1) averaged 60, 17, and 24% for pentagastrin, bethanechol, and histamine, respectively. Terbutaline also inhibited pentagastrin-stimulated acid secretion from vagally denervated fundic pouches in a dose-related manner. Plasma somatostatin-like immunoreactivity was significantly higher during infusion of terbutaline plus pentagastrin than during infusion of pentagastrin alone. However, an intravenous infusion of 0.3 microgram X kg-1 X h-1 somatostatin-14 had no effect on pentagastrin-stimulated acid secretion from the gastric fistula, even though this infusion increased plasma somatostatin-like immunoreactivity to the same extent as terbutaline plus pentagastrin infusion. Thus the amount of somatostatin released during terbutaline infusion was not sufficient to explain the inhibition of pentagastrin-stimulated acid secretion observed.

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A model study of the regulation of gastric acid secretion

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1989.257.1.g157 ◽

1989 ◽

Vol 257 (1) ◽

pp. G157-G168 ◽

Cited By ~ 2

Author(s):

B. Van Duijn ◽

D. L. Ypey ◽

J. de Goede ◽

A. A. Verveen ◽

W. Hekkens

Keyword(s):

Duodenal Ulcer ◽

Acid Secretion ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Gastric Volume ◽

Gastric Ph ◽

Food Storage ◽

Computer Simulation Model ◽

Gastrin Secretion ◽

Ph Dependent

A computer simulation model is presented of the gastric phase regulation of gastric acid secretion in humans. The model is based on experimental data from the literature and includes terms representing gastric pH and gastric volume-dependent gastrin secretion, gastrin-dependent acid secretion, food storage in the stomach, and gastric emptying. We have explored the predictive value of the model in assessing the relative importance of gastric pH-dependent and gastric volume-dependent acid secretion mechanisms under various conditions. Similarly we have studied the role of gastric acid deregulation in achlorhydria, the Zollinger-Ellison syndrome, and duodenal ulcer, and the influence of the antacid drugs cimetidine and ranitidine under duodenal ulcer conditions. Model analysis of normal gastric acid regulation suggests that gastric volume-controlled acid secretion is of major importance during eating and predicts that pH-dependent gastrin secretion is of major importance in preventing excessively low pH levels between meals and during the night.

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Pentapeptide and Insulin Stimulated Gastric Acid Secretion in Patients with Duodenal Ulcer before and after Selective Gastric Vagotomy and Antrum Drainage

Annals of Surgery ◽

10.1097/00000658-197211000-00013 ◽

1972 ◽

Vol 176 (5) ◽

pp. 649-652 ◽

Cited By ~ 4

Author(s):

E. KRAGELUND ◽

E. AMDRUP ◽

H. -E. JENSEN

Keyword(s):

Duodenal Ulcer ◽

Acid Secretion ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Before And After

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Effect of catecholamines on somatostatin secretion by isolated perfused rat stomach

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1981.240.3.e274 ◽

1981 ◽

Vol 240 (3) ◽

pp. E274-E278

Author(s):

Y. Goto ◽

M. Berelowitz ◽

L. A. Frohman

Keyword(s):

Acid Secretion ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Inhibitory Effect ◽

Dependent Manner ◽

Rat Stomach ◽

Beta Adrenergic ◽

Somatostatin Secretion ◽

Adrenergic Mechanism ◽

Dose Dependent

The secretion of somatostatin-like immunoreactivity (SRIF-LI) by the isolated perfused rat stomach was studied in response to stimulation by catecholamines. Gastric SRIF-LI secretion was significantly stimulated in a dose-dependent manner by norepinephrine at 10(-6) and 10(-8) M, and the effect of norepinephrine (10(-8) M) was attenuated by the addition of propranolol (10(-6) M) but not of phentolamine (10(-6) M). SRIF-LI secretion was also stimulated by dopamine at concentrations of 10(-4) and 10(-6) M but not at 10(-8) M. The effect of dopamine (10(-6) M) was not altered by the addition of haloperidol (10(-4) to 10(-7)) or metoclopramide (10(-4) M), and bromocriptine (10(-6) M) was without effect on SRIF-LI secretion. These results suggest that gastric SRIF-LI secretion is stimulated by a beta-adrenergic mechanism and raise the possibility that gastric somatostatin contributes to the inhibitory effect of norepinephrine on gastric acid secretion.

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