Synthesis and Characterization of Related Compounds of Aripiprazole, an Antipsychotic Drug Substance

2007 ◽  
Vol 37 (24) ◽  
pp. 4337-4341 ◽  
Author(s):  
T. Poorna Chander ◽  
B. Satyanarayana ◽  
N. Ramesh Kumar ◽  
P. Pratap Reddy ◽  
Y. Anjaneyulu
Keyword(s):  
Antipsychotic Drug ◽  
Drug Substance ◽  
Synthesis And Characterization ◽  
Related Compounds

scholarly journals Synthesis and Characterization of Potential Impurities of Eltrombopag Olamine

2020 ◽  
Vol 33 (1) ◽  
pp. 97-102
Author(s):  
Katuroju Srinivasachary ◽  
Chennuri Rajesh ◽  
Shashikant Tiwari ◽  
Y.S. Somannavar ◽  
Sailendra Kumar Nadakudity ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Drug Substance ◽  
Synthesis And Characterization

This work reports the feasibility of recently developed industrial viable process for eltrombopag olamine starting from 2-bromo-6-nitro phenol and reports the identification of four potential impurities related to eltrombopag olamine, namely eltrombopag olamine ester (1), 2-aminophenol analogue of eltrombopag (2), 3,3′-(2-amino-3-oxo-3H-phenoxazine-4,6-diyl dibenzoic acid (3), 2′-hydroxy[1,1- biphenyl]-3-carboxylic acid (4). These impurities are the crucial components in determining the quality of the drug substance, eltrombopag olamine during its manufacturing. These impurities have impact on the quality of eltrombopag olamine and controlled these impurities results excellent yields of active pharma ingredient of eltrombopag olamine

SYNTHESIS AND CHARACTERIZATION OF N-OXIDES AND METABOLITES OF ANTIPSYCHOTIC DRUG, ARIPIPRAZOLE

2005 ◽  
Vol 11 (6) ◽  
pp. 485-490
Author(s):  
Bollikonda Satyanarayana ◽  
Yasareni Sumalatha ◽  
Sythana Suresh Kumar ◽  
Sundaram Venkatraman ◽  
Ghanta Mahesh Reddy ◽  
...  
Keyword(s):  
Antipsychotic Drug ◽  
Synthesis And Characterization
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