Cloud Point Phenomenon in Amphiphilic Drug Promethazine Hydrochloride+Electrolyte Systems

Effect of two amphiphilic drugs (tricyclic antidepressant, nortriptyline hydrochloride (NORT), and nonsteroidal anti-inflammatory drug, sodium salt of ibuprofen (IBF)) on the cloud point of biopolymer hydroxypropylmethyl cellulose (HPMC) was studied. Effect of NaCl was also seen on the CP of HPMC-drug system. CP of HPMC increases uniformly on increasing the (drug). Both drugs, though one being anionic (IBF) and other cationic (NORT), affect the CP in almost the same manner but with different extent implying the role of hydrophobicity in the interaction between drug and polymer. Salt affects the CP of the drug in a dramatic way as low concentration of salt was only able to increase the value of the CP, though not affecting the pattern. However, in presence of high concentration of salts, minimum was observed on CP versus (drug) plots. Various thermodynamic parameters were evaluated and discussed on the basis of the observed results.

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Influence of electrolytes/non-electrolytes on the cloud point phenomenon of the aqueous promethazine hydrochloride drug solution

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2006.10.021 ◽

2007 ◽

Vol 306 (1) ◽

pp. 161-165 ◽

Cited By ~ 36

Author(s):

Md. Sayem Alam ◽

Andleeb Z. Naqvi ◽

Kabir-ud-Din

Keyword(s):

Cloud Point ◽

Promethazine Hydrochloride ◽

Drug Solution

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Cloud Point Phenomenon in Amphiphilic Drug Solutions

Langmuir ◽

10.1021/la0262102 ◽

2002 ◽

Vol 18 (26) ◽

pp. 10105-10108 ◽

Cited By ~ 85

Author(s):

Eui Jung Kim ◽

Dinesh O. Shah

Keyword(s):

Cloud Point ◽

Amphiphilic Drug

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Micellization behavior of the amphiphilic drug promethazine hydrochloride with 1-decyl-3-methylimidazolium chloride and its thermodynamic characteristics

Journal of Molecular Liquids ◽

10.1016/j.molliq.2014.07.021 ◽

2014 ◽

Vol 198 ◽

pp. 341-346 ◽

Cited By ~ 26

Author(s):

Abbul Bashar Khan ◽

Maroof Ali ◽

Neeraj Dohare ◽

Prashant Singh ◽

Rajan Patel

Keyword(s):

Thermodynamic Characteristics ◽

Amphiphilic Drug ◽

Promethazine Hydrochloride ◽

Micellization Behavior

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Clouding behavior of antidepressant drug–additive system in ethylene glycol/glycerol–water mixed media and their thermodynamic parameters at cloud point

New Journal of Chemistry ◽

10.1039/c7nj04369d ◽

2018 ◽

Vol 42 (6) ◽

pp. 4402-4411 ◽

Cited By ~ 5

Author(s):

Ajmal Koya Pulikkal ◽

Jackson Gurung

Keyword(s):

Ethylene Glycol ◽

Thermodynamic Parameters ◽

Cloud Point ◽

Antidepressant Drug ◽

Mixed Media ◽

Inorganic Salts ◽

Glycerol Water ◽

Additive System ◽

Amphiphilic Drug ◽

Amitriptyline Hydrochloride

The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic drug, amitriptyline hydrochloride was studied in presence and absence of inorganic salts in selected compositions of EG–WR and GL–WR mixed media.

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