Safety of haem arginate in overdose: report of an uneventful fourfold accidental overdose

The use of barbiturates in the treatment of insomnia carries a constant risk of habituation and of fatal poisoning from suicidal or accidental overdose. For these reasons, new non-barbiturate hypnotics deserve the closest attention. Ethinamate (“Valmidate”) and methyprylone (“Noludar”) are two such drugs. No trial comparing the hypnotic efficacy of ethinamate with a barbiturate has yet been reported, though Gruber et al. (1954) found the day-time sedative effect of 500 mg. ethinamate to be less (in duration of action) than 100 mg. of quinalbarbitone sodium. Methyprylone has been compared with barbiturate by Stewart (1956) who found 200 mg. equivalent to 100 mg. of amylo- or butobarbitone, by Lasagna (1956) who found 250 mg. equivalent to 100 mg. of pento- or quinal-barbitone, and by Thomson (1958) who found 400 mg. equivalent to 100 mg. of quinalbarbitone.

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Accidental overdose among injecting drug users in Dorset, UK

Addiction ◽

10.1046/j.1360-0443.1999.94811798.x ◽

1999 ◽

Vol 94 (8) ◽

pp. 1179-1189 ◽

Cited By ~ 50

Author(s):

Gerald A. Bennett ◽

David S. Higgins

Keyword(s):

Drug Users ◽

Injecting Drug Users ◽

Accidental Overdose

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Accidental overdose with phenprocoumon: VigiBase reports

Reactions Weekly ◽

10.1007/s40278-019-61504-3 ◽

2019 ◽

Vol 1752 (1) ◽

pp. 1-1

Keyword(s):

Accidental Overdose

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Accidental Overdose of "Parstelin."

BMJ ◽

10.1136/bmj.2.5321.1755-a ◽

1962 ◽

Vol 2 (5321) ◽

pp. 1755-1756 ◽

Cited By ~ 2

Author(s):

R. E. Midwinter

Keyword(s):

Accidental Overdose

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Changes in Pharmacistsʼ Perceptions After a Training in Opioid Misuse and Accidental Overdose Prevention

Journal of Continuing Education in the Health Professions ◽

10.1097/ceh.0000000000000233 ◽

2019 ◽

Vol 39 (1) ◽

pp. 7-12 ◽

Cited By ~ 9

Author(s):

Heidi N. Eukel ◽

Elizabeth Skoy ◽

Amy Werremeyer ◽

Siri Burck ◽

Mark Strand

Keyword(s):

Opioid Misuse ◽

Overdose Prevention ◽

Accidental Overdose

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Safety of newer generation anti-epileptic drugs in non-accidental overdose: an Irish population study

Seizure ◽

10.1016/j.seizure.2004.02.005 ◽

2005 ◽

Vol 14 (3) ◽

pp. 151-156 ◽

Cited By ~ 11

Author(s):

S. Sukumaran ◽

J. Herbert ◽

J. Tracey ◽

N. Delanty

Keyword(s):

Population Study ◽

Irish Population ◽

Accidental Overdose

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Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol

Current Gerontology and Geriatrics Research ◽

10.1155/2011/624156 ◽

2011 ◽

Vol 2011 ◽

pp. 1-14 ◽

Cited By ~ 33

Author(s):

Sarah J. Mitchell ◽

Alice E. Kane ◽

Sarah N. Hilmer

Keyword(s):

Older Adults ◽

Hepatic Clearance ◽

Optimal Dose ◽

Interindividual Variation ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Selection ◽

Age Related ◽

Accidental Overdose ◽

Toxicity Of Drugs ◽

Age Related Changes

Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.

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