Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread

2021 ◽  
pp. 1943274
Author(s):  
Sharof Tugizov
Keyword(s):  
Tight Junctions ◽  
Viral Transmission ◽  
Epithelial Tight Junctions

scholarly journals Rab13 regulates PKA signaling during tight junction assembly

2004 ◽  
Vol 165 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Katja Köhler ◽  
Daniel Louvard ◽  
Ahmed Zahraoui
Keyword(s):  
Tight Junction ◽  
Tight Junctions ◽  
Inhibitory Effect ◽  
Cell Junctions ◽  
Unknown Mechanism ◽  
Epithelial Tight Junctions ◽  
Actin Remodelling ◽  
Cell Cell

The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) through a yet unknown mechanism. Here, we show that expression of the GTP-bound form of Rab13 inhibits PKA-dependent phosphorylation and TJ recruitment of the vasodilator-stimulated phosphoprotein, an actin remodelling protein. We demonstrate that Rab13GTP directly binds to PKA and inhibits its activity. Interestingly, activation of PKA abrogates the inhibitory effect of Rab13 on the recruitment of vasodilator-stimulated phosphoprotein, ZO-1, and claudin1 to cell–cell junctions. Rab13 is, therefore, the first GTPase that controls PKA activity and provides an unexpected link between PKA signaling and the dynamics of TJ assembly.

scholarly journals Alterations in alveolar epithelial tight junctions induced by chronic ethanol ingestion

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Michael Koval ◽  
Alberto L Fernandez ◽  
Pratibha C Joshi ◽  
David M Guidot
Keyword(s):  
Tight Junctions ◽  
Chronic Ethanol ◽  
Ethanol Ingestion ◽  
Alveolar Epithelial ◽  
Epithelial Tight Junctions

scholarly journals Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice

2019 ◽  
Vol 118 ◽  
pp. 109206 ◽  
Author(s):  
Qiuke Hou ◽  
Shuilian Zhu ◽  
Changrong Zhang ◽  
Yongquan Huang ◽  
Yajuan Guo ◽  
...  
Keyword(s):  
Tight Junctions ◽  
Intestinal Epithelial ◽  
Epithelial Tight Junctions

Effects of Multipurpose Solutions on Corneal Epithelial Tight Junctions

2008 ◽  
Vol 34 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Masaki Imayasu ◽  
Atsushi Shiraishi ◽  
Yuichi Ohashi ◽  
Shoichi Shimada ◽  
H Dwight Cavanagh
Keyword(s):  
Tight Junctions ◽  
Corneal Epithelial ◽  
Epithelial Tight Junctions
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