Atomoxetine Versus Placebo in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder and Comorbid Oppositional Defiant Disorder: A Double-Blind, Randomized, Multicenter Trial in Germany

2011 ◽  
Vol 21 (2) ◽  
pp. 97-110 ◽  
Author(s):  
Ralf W. Dittmann ◽  
Alexander Schacht ◽  
Karin Helsberg ◽  
Christian Schneider-Fresenius ◽  
Martin Lehmann ◽  
...  
2017 ◽  
Vol 5 (2) ◽  
pp. 39-46 ◽  
Author(s):  
Milena Pereira Pondé ◽  
Mirella Lins Matos ◽  
Cinthia Cristina Pinto Bispo de Oliveira

Aim:  To estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD) in children and adolescents previously diagnosed with autism spectrum disorder (ASD). Methods:  A cross-sectional study involving 71 children and adolescents previously diagnosed by a psychiatrist as having ASD.  All were enrolled at a school that accompanies only individuals with ASD.  The evaluation instruments consisted of a sociodemographic questionnaire and the Brazilian version of the semi-structured interview Kiddie-SADS-PL for the investigation of psychiatric disorders in children and adolescents.  Results:  Overall, 62% of the children in the sample had some psychiatric comorbidity: 49.3% had some form of ADHD, 11.3% ODD and 1.4% CD.   In relation to the children with ADHD, 11.3% fulfilled the criteria for the inattentive subtype, 12.7% for the hyperactive/impulsive subtype, 7.1% for the combined subtype and 18.3% for ADHD not otherwise specified.  Conclusion:  These results ratify the clinical heterogeneity of ASD and highlight the importance of diagnosing comorbidities that could affect the clinical status and functioning level of children and adolescents with ASD.


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