scholarly journals Oxfold: kinetic folding of RNA using stochastic context-free grammars and evolutionary information

2013 ◽  
Vol 29 (6) ◽  
pp. 704-710 ◽  
Author(s):  
James W. J. Anderson ◽  
Pierre A. Haas ◽  
Leigh-Anne Mathieson ◽  
Vladimir Volynkin ◽  
Rune Lyngsø ◽  
...  
2015 ◽  
Vol 150 ◽  
pp. 147-154 ◽  
Author(s):  
Francisco Álvaro ◽  
Francisco Cruz ◽  
Joan-Andreu Sánchez ◽  
Oriol Ramos Terrades ◽  
José-Miguel Benedí

Author(s):  
ISMAEL SALVADOR ◽  
JOSÉ-MIGUEL BENEDÍ

The RNA sentences present structured regions caused by pairwise correlations, and nonstructured regions where any global relation can be found. In this paper, we present a combination of stochastic context-free grammars (SCFG) and bigram models. The SCFGs are used to represent the long-term relations of the structured part of RNA sequences, while the bigram models are used to capture the local relations of the nonstructured part. A stochastic version of Sakakibara's algorithm is used to study the SCFGs. Finally, experiments to evaluate the behavior of this proposal were carried out.


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