Comparison of biphasic and monophasic defibrillation waveforms in an isolated rabbit heart preparation

1991 ◽  
Vol 25 (12) ◽  
pp. 979-983 ◽  
Author(s):  
L. K Holley ◽  
R. M McCulloch
Keyword(s):  
Rabbit Heart ◽  
Isolated Rabbit Heart ◽  
Heart Preparation

scholarly journals Role of the perinodal region in atrioventricular nodal reentry: Evidence in an isolated rabbit heart preparation

1983 ◽  
Vol 2 (3) ◽  
pp. 465-473 ◽  
Author(s):  
Hiroyuki Iinuma ◽  
Leonard S. Dreifus ◽  
Todor Mazgalev ◽  
Rohn Price ◽  
Eric L. Michelson
Keyword(s):  
Rabbit Heart ◽  
Isolated Rabbit Heart ◽  
Heart Preparation

scholarly journals Impaired Myocardial Function and Oxygen Utilization Due to Protamine Sulfate in an Isolated Rabbit Heart Preparation

1990 ◽  
Vol 212 (4) ◽  
pp. 387-394 ◽  
Author(s):  
THOMAS W. WAKEFIELD ◽  
LARRY E. BIES ◽  
SHIRLEY K. WROBLESKI ◽  
STEVEN F. BOLLING ◽  
JAMES C. STANLEY ◽  
...  
Keyword(s):  
Myocardial Function ◽  
Rabbit Heart ◽  
Protamine Sulfate ◽  
Oxygen Utilization ◽  
Isolated Rabbit Heart ◽  
Heart Preparation

Comparative Ventricular Electrophysiologic Effect of Racemic Bupivacaine, Levobupivacaine, and Ropivacaine on the Isolated Rabbit Heart

2000 ◽  
Vol 93 (3) ◽  
pp. 784-792 ◽  
Author(s):  
Jean Xavier Mazoit ◽  
Anne Decaux ◽  
Hervé Bouaziz ◽  
Alain Edouard
Keyword(s):  
Rabbit Heart ◽  
Rate Dependence ◽  
Maximum Increase ◽  
Mixed Effect ◽  
Free Concentration ◽  
Isolated Rabbit Heart ◽  
Rate Dependent ◽  
Heart Preparation ◽  
Qrs Duration ◽  
Ventricular Conduction

Background Numerous local anesthetics have an asymmetric tetrahedron carbon, which confers stereoselective differences between the isomers. The authors attempted to quantify the depressant effect of racemic bupivacaine, levobupivacaine, and ropivacaine on myocardial ventricular conduction and on myocardial contractility. Methods The authors studied the pharmacokinetics (outflow concentration) and pharmacodynamics (QRS widening) of the three drugs infused in an isolated rabbit heart preparation. All data were fitted simultaneously with use of mixed-effect modeling, thus allowing precise statistical comparison between the three drug parameters. The rate dependence of QRS widening was fitted separately. Results Racemic bupivacaine, levobupivacaine, and ropivacaine induced a calculated maximum increase in QRS duration in the ratio 1:0.4:0.3. Css50, the dose which caused half the maximum increase in QRS duration at steady state, was similar for all three drugs (22 micrometer free concentration). A rate dependence of QRS widening was observed, which was in the ratio 1:0.5:0.25 for racemic bupivacaine, levobupivacaine, and ropivacaine, respectively. Conclusions In the isolated rabbit heart, racemic bupivacaine, levobupivacaine, and ropivacaine induce an increase in QRS duration in the respective ratio of 1:0.4:0.3, which was rate dependent in approximately the same ratio.

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