scholarly journals Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum

2002 ◽  
Vol 50 (2) ◽  
pp. 177-187 ◽  
Author(s):  
B. Pradines
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
Iron Chelators ◽  
In Vitro Activity ◽  
Antimalarial Agents

scholarly journals In Vitro Activity of Lumefantrine (Benflumetol) against Clinical Isolates of Plasmodium falciparum in Yaoundé, Cameroon

1998 ◽  
Vol 42 (9) ◽  
pp. 2347-2351 ◽  
Author(s):  
Leonardo K. Basco ◽  
Jean Bickii ◽  
Pascal Ringwald
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Activity ◽  
Geometric Mean ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
Cross Resistance ◽  
In Vitro Activity ◽  
Antimalarial Agents ◽  
Fluorene Derivative

ABSTRACT The in vitro antimalarial activity of the new Chinese synthetic drug, lumefantrine, also known as benflumetol (a fluorene derivative belonging to the aminoalcohol class), was determined by an isotopic microtest against 61 fresh clinical isolates of Plasmodium falciparum and compared with that of other established antimalarial agents. The geometric mean 50% inhibitory concentration of lumefantrine was 11.9 nmol/liter (95% confidence intervals, 10.4 to 13.6 nmol/liter; range, 3.3 to 25.6 nmol/liter). The in vitro activities of lumefantrine against the chloroquine-sensitive and the chloroquine-resistant isolates did not differ (P > 0.05). There was a significant positive correlation of responses between lumefantrine and two other aminoalcohols studied, mefloquine (r = 0.688) and halofantrine (r = 0.677), and between lumefantrine and artesunate (r = 0.420), suggesting a potential for in vitro cross-resistance. Our data suggest high in vitro activity of lumefantrine, comparable to that of mefloquine, and are in agreement with the promising results of preliminary clinical trials.

scholarly journals In Vitro Activity of Tafenoquine against the Asexual Blood Stages of Plasmodium falciparum Isolates from Gabon, Senegal, and Djibouti

2006 ◽  
Vol 50 (9) ◽  
pp. 3225-3226 ◽  
Author(s):  
Bruno Pradines ◽  
Modeste Mabika Mamfoumbi ◽  
Adama Tall ◽  
Cheikh Sokhna ◽  
Jean-Louis Koeck ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140878 ◽  
Author(s):  
Chandima S. K. Rajapakse ◽  
Maryna Lisai ◽  
Christiane Deregnaucourt ◽  
Véronique Sinou ◽  
Christine Latour ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
In Vitro Activity

Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum

2011 ◽  
Vol 138 (2) ◽  
pp. 637-640 ◽  
Author(s):  
Risoleta Ortet ◽  
Soizic Prado ◽  
Erik L. Regalado ◽  
Frederick A. Valeriote ◽  
Joseph Media ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum

2003 ◽  
Vol 8 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Jerome Mezui Me Ndong ◽  
Christiane Atteke ◽  
Agnes Aubouy ◽  
Mohamed Bakary ◽  
Jacques Lebibi ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
In Vitro Activity

In Vitro Activity of Bisquinoline WR268,668 Against African Clones and Isolates of Plasmodium falciparum

1994 ◽  
Vol 50 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Leonardo K. Basco ◽  
Wilbur K. Milhous ◽  
Jonathan L. Vennerstrom ◽  
Steven L. Andersen ◽  
Jacques Le Bras
Keyword(s):  
Plasmodium Falciparum ◽  
Vitro Activity ◽  
In Vitro Activity
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