scholarly journals Effect of captopril treatment on recuperation from ischemia/reperfusion-induced acute renal injury

2011 ◽  
Vol 27 (1) ◽  
pp. 136-145 ◽  
Author(s):  
S. Efrati ◽  
S. Berman ◽  
R. A. Hamad ◽  
Y. Siman-Tov ◽  
E. Ilgiyaev ◽  
...  
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Acute Renal Injury ◽  
Captopril Treatment

OLPRINONE REDUCES ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL INJURY IN RATS THROUGH ENHANCEMENT OF cAMP

Shock ◽  
2005 ◽  
Vol 24 (3) ◽  
pp. 281-287 ◽  
Author(s):  
Akio Mizutani ◽  
Kazunori Murakami ◽  
Kenji Okajima ◽  
Shin-ichiro Kira ◽  
Sachiko Mizutani ◽  
...  
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Acute Renal Injury

Room G, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Cepharanthine Reduces Ischemia/Reperfusion-Induced Acute Renal Injury by Inhibiting Leukocyte Activation in Rats 

2000 ◽  
Vol 93 (3A) ◽  
pp. A-430
Author(s):  
Akio Mizutani ◽  
Shigenori Yoshitake ◽  
Takayuki Noguchi ◽  
Kazunori Murakami ◽  
Kenji Okajima
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Leukocyte Activation ◽  
Acute Renal Injury

Role of Calcitonin Gene-Related Peptide in Ischemia/Reperfusion-Induced Acute Renal Injury in Rats

2002 ◽  
Vol 96 (Sup 2) ◽  
pp. A386
Author(s):  
Akio Mizutani ◽  
Kenji Okajima ◽  
Kazunori Murakami ◽  
Takayuki Noguchi ◽  
Daniel L. Traber
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Calcitonin Gene Related Peptide ◽  
Acute Renal Injury ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion

2011 ◽  
Vol 179 (6) ◽  
pp. 2766-2778 ◽  
Author(s):  
Yu Qin ◽  
Maaike C. Alderliesten ◽  
Geurt Stokman ◽  
Petra Pennekamp ◽  
Joseph V. Bonventre ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Kinase Signaling ◽  
Acute Renal Injury ◽  
Focal Adhesion Kinase Signaling

Effects of ischemia-reperfusion injury on renal ammonia metabolism and the collecting duct

2007 ◽  
Vol 293 (4) ◽  
pp. F1342-F1354 ◽  
Author(s):  
Ki-Hwan Han ◽  
Hye-Young Kim ◽  
Byron P. Croker ◽  
Sirirat Reungjui ◽  
Su-Youn Lee ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Proximal Tubule ◽  
Renal Injury ◽  
Collecting Duct ◽  
Ischemia Reperfusion ◽  
Ammonia Excretion ◽  
Intercalated Cells ◽  
Acute Renal Injury ◽  
Intercalated Cell ◽  
Medullary Collecting Duct

Acute renal injury induces metabolic acidosis, but its specific effects on the collecting duct, the primary site for urinary ammonia secretion, the primary component of net acid excretion, are incompletely understood. We induced ischemia-reperfusion (I/R) acute renal injury in Sprague-Dawley rats by clamping the renal pedicles bilaterally for 30 min followed by reperfusion for 6 h. Control rats underwent sham surgery without renal pedicle clamping. I/R injury decreased urinary ammonia excretion significantly but did not persistently alter urine volume, Na+, K+, or bicarbonate excretion. Histological examination demonstrated cellular damage in the outer and inner medullary collecting duct, as well as in the proximal tubule and the thick ascending limb of the loop of Henle. A subset of collecting duct cells were damaged and/or detached from the basement membrane; these cells were present predominantly in the outer medulla and were less frequent in the inner medulla. Immunohistochemistry identified that the damaged/detached cells were A-type intercalated cells, not principal cells. Both TdT-mediated dUTP nick-end labeling (TUNEL) staining and transmission electron microscopic examination demonstrated apoptosis but not necrosis. However, immunoreactivity for caspase-3 was observed in the proximal tubule, but not in collecting duct intercalated cells, suggesting that mechanism(s) of collecting duct intercalated cell apoptosis differ from those operative in the proximal tubule. We conclude that I/R injury decreases renal ammonia excretion and is associated with intercalated cell-specific detachment and apoptosis in the outer and inner medullary collecting duct. These effects likely contribute to the metabolic acidosis frequently observed in acute renal injury.

Effects of total glucosides of paeony on acute renal injury following ischemia-reperfusion via the lncRNA HCG18/miR-16-5p/Bcl-2 axis

Immunobiology ◽  
2022 ◽  
pp. 152179
Author(s):  
Wei Zhao ◽  
Yuan Zhang ◽  
Mingzhu Zhang ◽  
Yong Zhi ◽  
Xiaohan Li ◽  
...  
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Acute Renal Injury ◽  
Total Glucosides Of Paeony

LIDOCAINE REDUCES ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL INJURY BY INHIBITING LEUKOCYTE ACTIVATION IN RATS

1999 ◽  
Vol 27 (Supplement) ◽  
pp. A123
Author(s):  
Akio Mizutani ◽  
Shigenori Yoshitake ◽  
Kyosuke Kudo ◽  
Takayuki Noguchi ◽  
Mitsuhiro Uchiba ◽  
...  
Keyword(s):  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Leukocyte Activation ◽  
Acute Renal Injury
Sign in / Sign up

Export Citation Format

Share Document