Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG

Abstract The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health and quality of life by accelerating progress in cancer-related research through collaboration. Under this umbrella, the NCRI Brain Tumor Clinical Studies Group is focused on improving clinical outcomes for adult patients with brain and central nervous system tumors, including those with brain metastasis from other primary sites. This document discusses the current state of clinical brain tumor research in the United Kingdom and the challenges to increasing study and trial opportunities for patients. The clinical research priorities are defined along with a strategy to strengthen the existing brain tumor research network, improve access to tissue and imaging and to develop the future leadership for brain tumor research in the United Kingdom. This strategy document may serve as a framework for other organizations and countries.

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NCI Tackles Brain Tumor Research

PsycEXTRA Dataset ◽

10.1037/e572632006-004 ◽

2000 ◽

Keyword(s):

Brain Tumor ◽

Tumor Research ◽

Brain Tumor Research

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GE-11 * THE FLORIDA CENTER FOR BRAIN TUMOR RESEARCH (FCBTR): BUILDING INFRASTRUCTURE TO FIND A CURE

Neuro-Oncology ◽

10.1093/neuonc/nou256.11 ◽

2014 ◽

Vol 16 (suppl 5) ◽

pp. v98-v98

Author(s):

B. Frentzen, ◽

D. Mitchell, ◽

W. A. Friedman ◽

A. Yachnis ◽

R. McTiernan

Keyword(s):

Brain Tumor ◽

Tumor Research ◽

Brain Tumor Research

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Research Funding for Stem Cells and CancerOpportunities for Brain Tumor Research

Neurosurgery ◽

10.1227/01.neu.0000307619.58624.7d ◽

2007 ◽

Keyword(s):

Stem Cells ◽

Brain Tumor ◽

Research Funding ◽

Tumor Research ◽

Brain Tumor Research

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Thirteenth International Conference on Brain Tumor Research and TherapyOctober 4–6, 1999 Sapporo, Japan

Neuro-Oncology ◽

10.1093/neuonc/1.abstract_issue_2.s75 ◽

1999 ◽

Keyword(s):

Brain Tumor ◽

International Conference ◽

Tumor Research ◽

Brain Tumor Research

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COT-11 EFFECT OF PHYSICIAN SUPPORTS ON QUALITY CONTROL AND QUALITY ASSURANCE IN CLINICAL BRAIN TUMOR RESEARCH

Neuro-Oncology Advances ◽

10.1093/noajnl/vdz039.191 ◽

2019 ◽

Vol 1 (Supplement_2) ◽

pp. ii42-ii42

Author(s):

Keiko Furukawa ◽

Yoshiki Arakawa ◽

Yohei Mineharu ◽

Masahiro Tanji ◽

Akifumi Takaori ◽

...

Keyword(s):

Quality Control ◽

Clinical Trials ◽

Quality Assurance ◽

Brain Tumor ◽

Ethical Review ◽

Evaluation Score ◽

Periodic Monitoring ◽

Tumor Research ◽

Brain Tumor Research ◽

Physician Support

Abstract BACKGROUND Clinical physicians have difficulties in conducting investigator-initiated-trials because of increasing clinical duties in Japan. Therefore, physician support can be one of the important factors for quality control and quality assurance. In Kyoto University Hospital, clinical research professional’s support for physician had started at November 2012. In this study, we evaluate effect of physician supports on quality control and quality assurance in clinical brain tumor research. METHODS Our department of Neurosurgery has been a member of Brain Tumor Study Group in Japan Clinical Oncology Group (JCOG) since 2007. The number of registered patients, the status of periodic monitoring, the occurrence of inquiries per case, and details of physicians’ support (items, frequency, methods, etc.) in each clinical trial were investigated. The factors affecting the audit results conducted by JCOG Audit Committee on January 2013 and February 2019 are examined. RESULTS There are seven trials have been ongoing on or started since November 2012. There are fifty patients registered in the clinical studies until July 2019. Periodic monitoring has been carried out in 214 patients of cumulative total number since 2012. Physicians’ support mainly involved the preparation of ethical review documents, CRF documentation, responses to data queries, preparation of SAE reports, study schedule check and monitoring of observation items. The audit results of site visit were acceptable, total evaluation score 68.80 on January 2013 and excellent, total evaluation score 99.9 on February 2019. CONCLUSION Clinical Trials Act has been implemented, and further improvement in the quality of clinical trials has been demanded. As the results of this study, we clarified the necessity for physician support and the contribution to quality improvement.

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