scholarly journals Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Chrsitopher K. Taylor ◽  
D. David Smith ◽  
Peter W. Abel
Keyword(s):  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Pharmacological Characterization ◽  
High Affinity ◽  
Cgrp Receptor Antagonists

Identification and Pharmacological Characterization of Domains Involved in Binding of CGRP Receptor Antagonists to the Calcitonin-like Receptor

Biochemistry ◽  
2006 ◽  
Vol 45 (6) ◽  
pp. 1881-1887 ◽  
Author(s):  
Christopher A. Salvatore ◽  
John J. Mallee ◽  
Ian M. Bell ◽  
C. Blair Zartman ◽  
Theresa M. Williams ◽  
...  
Keyword(s):  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Pharmacological Characterization ◽  
Cgrp Receptor Antagonists

CGRP receptor antagonists for migraine – are they also AMY 1 receptor antagonists?

2021 ◽  
Author(s):  
Michael L. Garelja ◽  
Christopher S. Walker ◽  
Debbie L. Hay
Keyword(s):  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Cgrp Receptor Antagonists

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1

2012 ◽  
Vol 22 (14) ◽  
pp. 4723-4727 ◽  
Author(s):  
Xiaojun Han ◽  
Rita L. Civiello ◽  
Charles M. Conway ◽  
Deborah A. Cook ◽  
Carl D. Davis ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonists

scholarly journals Effect of Calcitonin Gene-Related Peptide Receptor Antagonists on Migraine Treatment: A Meta-Analysis

2021 ◽  
Author(s):  
Jiyoung Kim ◽  
Kyoungjune Pak ◽  
Gha-Hyun Lee ◽  
Jae Wook Cho ◽  
Hyun-Woo kim
Keyword(s):  
Meta Analysis ◽  
Calcitonin Gene Related Peptide ◽  
Migraine Treatment ◽  
Acute Migraine ◽  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonists ◽  
Acute Migraine Treatment

Abstract Background: The pathophysiology of migraine has been researched incessantly, and it has been suggested that calcitonin gene-related peptide (CGRP) is associated with migraine attacks. CGRP receptor blockers are attracting attention for migraine prevention and treatment of acute episodes, and CGRP receptor antagonists have been shown to be effective in treating acute migraine headaches. This meta-analysis aimed to assess the effect of available CGRP receptor antagonists, focusing on their therapeutic doses for acute migraine treatment.Methods: We performed a systematic search of MEDLINE (from inception to March 2021) and EMBASE (from inception to March 2021) for English publications using the keywords “migraine” and “Calcitonin gene-related peptide,” limited to human studies.Results: Five studies that focused on examining the effects of CGRP receptor antagonists on acute migraine treatment met the eligibility criteria for this meta-analysis. The pooled analysis demonstrated that the CGRP receptor antagonist improved freedom from pain (OR=2.066, 95% confidence interval [CI] 1.766–2.418, I2=0%), absence of bothersome symptoms (OR=1.606, 95% CI=1.408–1.830, I2=0%), pain relief (OR=1.791, 95% CI=1.598–2.008, I2=0%), and freedom from nausea (OR=1.361, 95% CI=1.196–1.548, I2=0%), significantly more than the placebo. Conclusions: CGRP receptor antagonists are effective for acute migraine treatment and are expected to be used clinically as emerging therapeutic agents.

Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists

1997 ◽  
Vol 7 (20) ◽  
pp. 2673-2676 ◽  
Author(s):  
Robert A. Daines ◽  
Kelvin K.C. Sham ◽  
Jack J. Taggart ◽  
William D. Kingsbury ◽  
James Chan ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonists
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