scholarly journals Effects of Parietal Cell Vagotomy on Acid and Pepsin Secretion in Gastric Fistula Dogs

1973 ◽  
Vol 178 (2) ◽  
pp. 204-208 ◽  
Author(s):  
ARI KAYNAN ◽  
CUR BEN-ARI ◽  
ALLAN E. KARK ◽  
JACK RUDICK
Keyword(s):  
Parietal Cell ◽  
Gastric Fistula ◽  
Pepsin Secretion ◽  
Parietal Cell Vagotomy

Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion

1983 ◽  
Vol 245 (6) ◽  
pp. G739-G744
Author(s):  
B. I. Hirschowitz ◽  
J. Fong
Keyword(s):  
Gastric Secretion ◽  
Parietal Cell ◽  
Acid Output ◽  
Gastric Fistula ◽  
Large Decrease ◽  
Pepsin Secretion ◽  
K Secretion ◽  
Inhibited Acid ◽  
K Concentration ◽  
Bethanechol Chloride

The final step in acid secretion is believed to result from the H+-K+-ATPase-mediated exchange of H+ in the parietal cell, with K+ in the lumen. To study the K+ secretion we used Picoprazole and insulin separately and together to inhibit gastric secretion stimulated in gastric fistula dogs with histamine (100 micrograms X kg-1 X h-1). Picoprazole, a substituted benzimidazole (750 mg/kg), reduced gastric H+ concentration and volume with a rise in K+ concentration [( K+]) to 20–25 meq/l. Insulin alone inhibited acid output to the same extent as Picoprazole but with a marked fall in [K+]. Insulin (0.6 U/kg) given with Picoprazole did not alter inhibition of H+ but prevented the large decrease in gastric juice [K+]. An injection of KCl (1 meq/kg) 1 h after Picoprazole did not alter the effects of the inhibitor. Pepsin secretion after insulin was delayed by Picoprazole, whereas during bethanechol chloride infusion (80 micrograms X kg-1 X h-1) pepsin output was reduced for a shorter period and to a lesser extent than acid. We concluded that insulin affects gastric H+ and K+ secretion by a mechanism not related to H+-K+-ATPase and that Picoprazole affects pepsin secretion probably indirectly via its effect on the parietal cell, where its action is quite consistent with an effect limited to inhibition of the H+-K+-ATPase of the parietal cell.

Parietal cell vagotomy for intractable and obstructing duodenal ulcer

1981 ◽  
Vol 141 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Ricardo L. Rossi ◽  
John W. Braasch ◽  
Blake Cady ◽  
Cornelius E. Sedgwick
Keyword(s):  
Duodenal Ulcer ◽  
Parietal Cell ◽  
Parietal Cell Vagotomy

scholarly journals Serial Studies of Gastric Secretion in Patients After Highly Selective (Parietal Cell) Vagotomy without a Drainage Procedure for Duodenal Ulcer

1973 ◽  
Vol 64 (1) ◽  
pp. 1-11 ◽  
Author(s):  
D. Johnston ◽  
A.R. Wilkinson ◽  
C.S. Humphrey ◽  
R.B. Smith ◽  
J.C. Goligher ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Secretion ◽  
Parietal Cell ◽  
Drainage Procedure ◽  
Parietal Cell Vagotomy
Sign in / Sign up

Export Citation Format

Share Document