DECREASED TYROSINE HYDROXYLASE ACTIVITY IN THE ADRENALS OF SPONTANEOUSLY HYPERTENSIVE RATS BEFORE AND AFTER DEVELOPMENT OF HYPERTENSION

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S125
Author(s):  
E. Moura ◽  
M. A. Vieira-Coelho
Keyword(s):  
Tyrosine Hydroxylase ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Hydroxylase Activity ◽  
Spontaneously Hypertensive ◽  
Tyrosine Hydroxylase Activity ◽  
Before And After

Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats

Life Sciences ◽  
2005 ◽  
Vol 76 (25) ◽  
pp. 2953-2964 ◽  
Author(s):  
Eduardo Moura ◽  
Paulo M. Pinho Costa ◽  
Daniel Moura ◽  
Serafim Guimarães ◽  
Maria A. Vieira-Coelho
Keyword(s):  
Tyrosine Hydroxylase ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Hydroxylase Activity ◽  
Spontaneously Hypertensive ◽  
Tyrosine Hydroxylase Activity

Biosynthetic Enzyme Activities and Catecholamines in Adrenal Glands of Genetic and Experimental Hypertensive Rats

1982 ◽  
Vol 63 (s8) ◽  
pp. 113s-116s ◽  
Author(s):  
Horst Grobecker ◽  
Juan Saavedra ◽  
Virginia Weise
Keyword(s):  
Tyrosine Hydroxylase ◽  
Adrenal Glands ◽  
Experimental Hypertension ◽  
Hypertensive Rats ◽  
Hydroxylase Activity ◽  
Spontaneously Hypertensive ◽  
Tyrosine Hydroxylase Activity ◽  
Catecholamine Synthesizing Enzymes ◽  
Wistar Kyoto ◽  
Genetically Hypertensive

1. There was a significant decrease in the activity of tryosine hydroxylase, dopamine-β-hydroxylase and phenylethanolamine-N-methyltransferase in young spontaneously hypertensive rats (SHR) at the age of 2 and 4 weeks, compared with the activity in adrenals of the Wistar-Kyoto rat substrain. Tyrosine hydroxylase activity was not different in normotensive and hypertensive animals at 8 weeks of age but was increased in adult SHR. 2. Both dopamine-β-hydroxylase and phenylethanolamine-N-methyltransferase activities were still decreased at the age of 8 weeks in SHR, but were not significantly different from the controls at the age of 14 weeks. Blood pressures in SHR were slightly but significantly higher at 4 weeks of age and steadily rose during maturation. 3. In DOCA-saline hypertensive rats, tyrosine hydroxylase activity in adrenals was increased after only 1 week of treatment and remained increased after 2 and 4 weeks of treatment. Adrenal adrenaline was increased after 4 weeks of treatment, whereas dopamine-β-hydroxylase and phenylethanolamine-N-methyltransferase activities and noradrenaline levels were unchanged. 4. Our findings of increased tyrosine hydroxylase in adrenal glands of adult genetically hypertensive and chronic experimentally hypertensive rats indicate a sympathoadrenal activation during the established phase of the hypertension in both models. Whereas in DOCA-saline hypertensive rats catecholamine synthesis in adrenals parallels the development of high blood pressure, in genetically hypertensive rats the activity of the catecholamine-synthesizing enzymes is decreased early in development. These results suggest the existence of different mechanisms regulating the participation of adrenal catecholamines in both models of experimental hypertension.

Elevated tyrosine hydroxylase mRNA levels in medulla oblongata of spontaneously hypertensive rats

1996 ◽  
Vol 36 (1) ◽  
pp. 197-199 ◽  
Author(s):  
Toshio Kumai ◽  
Masami Tanaka ◽  
Minoru Watanabe ◽  
Hironori Nakura ◽  
Tomonori Tateishi ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Medulla Oblongata ◽  
Spontaneously Hypertensive Rats ◽  
Mrna Levels ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Peripheral and Central Catecholaminergic Neurons in Genetic and Experimental Hypertension in Rats

1976 ◽  
Vol 51 (s3) ◽  
pp. 377s-380s ◽  
Author(s):  
H. Grobecker ◽  
J. M. Saavedra ◽  
M. F. Roizen ◽  
V. Weise ◽  
I. J. Kopin ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Adrenal Glands ◽  
Experimental Hypertension ◽  
Hypertensive Rats ◽  
Hydroxylase Activity ◽  
Methyl Transferase ◽  
Spontaneously Hypertensive ◽  
Catecholaminergic Neurons ◽  
Wistar Kyoto ◽  
The Brain

1. Activity of peripheral and central catecholaminergic neurons was studied in spontaneously hypertensive rats (SHR) and deoxycorticosterone (DOCA)—salt hypertensive rats. 2. In young SHR (4 weeks) the plasma values of both noradrenaline and dopamine-β-hydroxylase activity were increased compared with those of normotensive rats of the Wistar/Kyoto strain. Total catecholamines (mostly adrenaline) were not significantly different. 3. In the adrenal glands of 2-weeks-old and 4-weeks-old SHR activities of tyrosine hydroxylase, dopamine-β-hydroxylase, phenylethanolamine-N-methyl transferase were decreased, compared to Wistar/Kyoto rats. 4. The adrenaline-forming enzyme was elevated in the A1 and A2 regions of the brain stem of 4-weeks-old SHR and in the A1 region of adult DOCA—salt hypertensive rats. 5. In the adrenal glands of adult DOCA—salt hypertensive rats tyrosine hydroxylase activity was increased. 6. These results implicate peripheral noradrenaline-containing neurons and central adrenaline-containing neurons in the development of genetic and experimental hypertension in rats.

scholarly journals Dopamine β-Hydroxylase Activity in Stroke-prone Spontaneously Hypertensive Rats

1978 ◽  
Vol 19 (4) ◽  
pp. 641-641 ◽  
Author(s):  
Takeshi KATO ◽  
Toshiharu NAGATSU ◽  
Yoko HASHIMOTO ◽  
Yukiko NUMATA-SUDO ◽  
Yukio YAMORI ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Hydroxylase Activity ◽  
Spontaneously Hypertensive
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