Comparative Effects of a New Nicotinamide Nitrate Derivative, Nicorandil (SG 75), with Nifedipine and Nitroglycerin on True Collateral Blood Flow Following an Acute Coronary Occlusion in Dogs

1984 ◽  
Vol 6 (4) ◽  
pp. 601-608 ◽  
Author(s):  
Kathryn A. Lamping ◽  
Garrett J. Gross
Keyword(s):  
Blood Flow ◽  
Coronary Occlusion ◽  
Collateral Blood Flow ◽  
Acute Coronary Occlusion

Collateral blood flow in the border zone following acute coronary occlusion

1975 ◽  
Vol 35 (1) ◽  
pp. 136 ◽  
Author(s):  
Stephen J. Fischl ◽  
Edmund H. Sonnenblick ◽  
Edward S. Kirk
Keyword(s):  
Blood Flow ◽  
Coronary Occlusion ◽  
Border Zone ◽  
Collateral Blood Flow ◽  
Acute Coronary Occlusion

Blood pressure, heart rate, and adrenal catecholamines prior to ventricular fibrillation

1961 ◽  
Vol 201 (1) ◽  
pp. 109-111 ◽  
Author(s):  
Noel M. Bass ◽  
Vincent V. Glaviano
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Ventricular Fibrillation ◽  
Coronary Occlusion ◽  
Marked Decrease ◽  
Mean Blood Pressure ◽  
Plasma Adrenaline ◽  
Acute Coronary Occlusion ◽  
Before And After

Heart rate, mean blood pressure, adrenal blood flow, and adrenal plasma adrenaline and noradrenaline were compared before and after ligation of the anterior descending coronary artery in dogs anesthetized with chloralose. One group of 12 dogs responded to acute coronary occlusion with a sudden and marked decrease in mean blood pressure (mean, 31%) and heart rate (mean, 18%) followed by an early onset (mean, 227 sec) of ventricular fibrillation. Another group of nine dogs responded with slight decreases in mean blood pressure (mean, 13%) and heart rate (mean, 5%), during which time ventricular fibrillation occurred late (mean, 30 min) or not at all. While the two groups were statistically different in mean blood pressure and heart rate, the minute output of adrenal catecholamines in either group was not found to be related to the early or late occurrence of ventricular fibrillation.

Effects of time on volume and distribution of coronary collateral flow

1976 ◽  
Vol 230 (2) ◽  
pp. 279-285 ◽  
Author(s):  
ML Marcus ◽  
RE Kerber ◽  
J Ehrhardt ◽  
FM Abboud
Keyword(s):  
Blood Flow ◽  
Vascular Resistance ◽  
Coronary Occlusion ◽  
Marked Decrease ◽  
Relative Proportion ◽  
Collateral Flow ◽  
Coronary Vascular Resistance ◽  
Collateral Blood Flow ◽  
Coronary Collateral Flow ◽  
Hemodynamic Measurements

Changes in the volume and distribution of collateral blood flow were studied during the 1st h after coronary occlusion in nine open-chest dogs. Labeled microspheres (7-10 mum) were injected into the left atrium prior to and 20 s, 5 min, and 60 min after acute occlusion of the midcircumflex coronary artery so that myocardial perfusion to small segments of the entire left ventricle could be measured. The segmental perfusions were classified as normally perfused, severely hypoperfused, moderately hypoperfused, and borderline hypoperfused. Standard hemodynamic measurements were obtained and relative coronary vascular resistance to the normally perfused and hypoperfused zones was calculated. The principal conclusions of the study are as follows: 1) during the 1st h after coronary occlusion the collateral flow to the hypoperfused myocardium increases substantially; 2) the increase in collateral flow is distributed fairly evenly to various hypoperfused zones and is associated with a marked decrease in coronary vascular resistance; and 3) as a result of this influx in collateral flow the size of the hypoperfused area decreases and the relative proportion of severely hypoperfused segments within the hypoperfused area decreases.

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