Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Formation of Ventricular Arrhythmias Caused By Intrapericardial Infusion of Endothelin-1

2000 ◽  
Vol 36 ◽  
pp. S317-S319
Author(s):  
Orsolya Kiss ◽  
László Gellér ◽  
Béla Merkely ◽  
Tamás Szabó ◽  
Manfred Raschack ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ventricular Arrhythmias ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Formation of Ventricular Arrhythmias Caused By Intrapericardial Infusion of Endothelin-1

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S317-S319 ◽  
Author(s):  
Orsolya Kiss ◽  
Lászl Gellér ◽  
Béla Merkely ◽  
Tamás Szabó ◽  
Manfred Raschack ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ventricular Arrhythmias ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

The Selective Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Direct Arrhythmogenic Action of Endothelin-1

2000 ◽  
Vol 36 ◽  
pp. S314-S316 ◽  
Author(s):  
Béla Merkely ◽  
Tamás Szabó ◽  
László Gellér ◽  
Orsolya Kiss ◽  
Ferenc Horkay ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

Bosentan the Mixed Endothelin-A- and -B-Receptor Antagonist Suppresses Intrapericardial Endothelin-1-Induced Ventricular Arrhythmias

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S320-S322 ◽  
Author(s):  
Ferenc Horkay ◽  
Lászl Gellér ◽  
Orsolya Kiss ◽  
Tamás Szab ◽  
Hajnalka Vág ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ventricular Arrhythmias ◽  
Endothelin 1 ◽  
Endothelin A

Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibition prevents endothelin A receptor antagonism in rat aorta

2007 ◽  
Vol 292 (4) ◽  
pp. H1961-H1966 ◽  
Author(s):  
M. Tosun ◽  
Y. Erac ◽  
C. Selli ◽  
N. Karakaya
Keyword(s):  
Endoplasmic Reticulum ◽  
Receptor Antagonist ◽  
Cyclopiazonic Acid ◽  
Rat Aorta ◽  
Endothelin Receptor Antagonist ◽  
Endothelin Receptor ◽  
Atpase Inhibitor ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

This study tested whether sarcoplasmic-endoplasmic reticulum Ca2+-ATPase regulates the ability of endothelin receptor antagonist to inhibit the endothelin-1 constriction. The endothelin A receptor antagonist BQ-123 (1 μM) completely relaxed constriction to 10 nM endothelin-1 in endothelium-denuded rat aorta. Challenge with cyclopiazonic acid (10 μM), a sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibitor, during the plateau of endothelin-1 constriction enhanced the constriction by ∼30%. BQ-123 relaxed the endothelin-1 plus cyclopiazonic acid constriction by only ∼10%. In contrast, prazosin (1 μM), an α-adrenergic receptor antagonist, still completely relaxed the 0.3 μM phenylephrine constriction in the presence of cyclopiazonic acid. Verapamil relaxed the endothelin-1 plus cyclopiazonic acid constriction by ∼30%, whereas Ni2+ and 2-aminoethoxydiphenyl borate, nonselective cation channel and store-operated channel blockers, respectively, completely relaxed the constriction. These results suggest that lowered sarcoplasmic-endoplasmic reticulum Ca2+-ATPase activity selectively decreases the ability of endothelin receptor antagonist to inhibit the endothelin A receptor. The decreased antagonism may be related to the opening of store-operated channels and subsequent greater internalization of endothelin A receptor.

Bosentan the Mixed Endothelin-A- and -B-Receptor Antagonist Suppresses Intrapericardial Endothelin-1-Induced Ventricular Arrhythmias

2000 ◽  
Vol 36 ◽  
pp. S320-S322
Author(s):  
Ferenc Horkay ◽  
László Gellér ◽  
Orsolya Kiss ◽  
Tamás Szabó ◽  
Hajnalka Vágó ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ventricular Arrhythmias ◽  
Endothelin 1 ◽  
Endothelin A

scholarly journals The Selective Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Direct Arrhythmogenic Action of Endothelin-1

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S314-S316 ◽  
Author(s):  
Béla Merkely ◽  
Tamás Szab ◽  
Lászl Gellér ◽  
Orsolya Kiss ◽  
Ferenc Horkay ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

Endothelin-1-induced contraction of pulmonary arteries from endotoxemic rats is attenuated by the endothelin-A receptor antagonist, BQ123

1996 ◽  
Vol 24 (12) ◽  
pp. 2007-2013 ◽  
Author(s):  
Nicholas P. Curzen ◽  
Jane A. Mitchell ◽  
Karen B. Jourdan ◽  
Mark J. D. Griffiths ◽  
Timothy W. Evans
Keyword(s):  
Receptor Antagonist ◽  
Pulmonary Arteries ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

Effects of Endothelin-1 and Endothelin-A Receptor Antagonist on Recovery After Hypothermic Cardioplegic Ischemia in Neonatal Lamb Hearts

Circulation ◽  
1995 ◽  
Vol 92 (9) ◽  
pp. 400-404 ◽  
Author(s):  
Takeshi Hiramatsu ◽  
Joseph Forbess ◽  
Takuya Miura ◽  
Stephen J. Roth ◽  
Mark A. Cioffi MAT ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A

Evaluation of the Effect of Endothelin-1 and Characterization of the Selective Endothelin A Receptor Antagonist PD155080 in the Prostate

1997 ◽  
Vol 158 (1) ◽  
pp. 253-257 ◽  
Author(s):  
Chieko Imajo ◽  
Paul D. Walden ◽  
Ellen Shapiro ◽  
Annette M. Doherty ◽  
Herbert Lepor
Keyword(s):  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A
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