Dalteparin Sodium Treatment during Resuscitation Inhibits Hemorrhagic Shock-Induced Leukocyte Rolling and Adhesion in the Mesenteric Microcirculation

2002 ◽  
Vol 52 (6) ◽  
pp. 1062-1070 ◽  
Author(s):  
Zsolt Balogh ◽  
Antal Wolf??rd ◽  
L??szl?? Szalay ◽  
Edit Orosz ◽  
J??nos Aur??l Simonka ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Dalteparin Sodium ◽  
Leukocyte Rolling ◽  
Mesenteric Microcirculation

scholarly journals Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation

2014 ◽  
Vol 2 (11) ◽  
pp. e12199 ◽  
Author(s):  
Qiuhua Shen ◽  
Naomi Holloway ◽  
Amanda Thimmesch ◽  
John G. Wood ◽  
Richard L. Clancy ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Microvascular Inflammation ◽  
Mesenteric Microcirculation

A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits

1994 ◽  
Vol 267 (6) ◽  
pp. H2391-H2397 ◽  
Author(s):  
R. K. Winn ◽  
J. C. Paulson ◽  
J. M. Harlan
Keyword(s):  
Monoclonal Antibody ◽  
Endothelial Cells ◽  
Cardiac Output ◽  
Hemorrhagic Shock ◽  
Vascular Injury ◽  
Control Group ◽  
Leukocyte Rolling ◽  
Significant Protection ◽  
Shed Blood

P-selectin (CD62P) can participate in leukocyte rolling when it is expressed on the surface of endothelial cells. We examined the role of CD62P in hemorrhagic shock and resuscitation. Rabbits were treated with saline, an anti-CD62P (alpha-CD62P) monoclonal antibody (MAb; PB1.3), an isotype-matched MAb (PNB1.6), or an alpha-CD18 MAb (60.3). Catheters were placed in the femoral artery and vein for monitoring, and cardiac output was then reduced to 33% of baseline for 1.5 h. Shed blood was returned, and resuscitation was continued to maintain the cardiac output to within 90% of baseline. There were no statistical differences between the saline- and MAb PNB1.6-treated groups; they were therefore combined into a control group. The MAb PB1.3- and MAb 60.3-treated groups required significantly less fluid resuscitation than the controls (12, 17, and 56 ml/kg, respectively). We conclude that MAbs directed to functional epitopes of either CD62P or CD18 provide significant protection from vascular injury after hemorrhagic shock.

Effects of remifentanil on mesenteric microcirculation in hemorrhagic shock rats

2010 ◽  
Vol 29 (12) ◽  
pp. 1426-1428
Author(s):  
Fang LIAN ◽  
Gui-ning LIANG ◽  
Mei FENG ◽  
Shu-rong MO
Keyword(s):  
Hemorrhagic Shock ◽  
Mesenteric Microcirculation

Shiga toxin stimulates leukocyte adhesion in rat mesenteric microcirculation in vivo

2001 ◽  
Vol 120 (5) ◽  
pp. A195-A195
Author(s):  
E OLOUGHLIN ◽  
C SIM ◽  
M PERRY ◽  
E ELLIOTT ◽  
Z LI
Keyword(s):  
Shiga Toxin ◽  
Leukocyte Adhesion ◽  
Mesenteric Microcirculation
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