EFFECTS OF ADRENALINE AND NORADRENALINE ON CORONARY BLOOD FLOW BEFORE AND AFTER BETA-ADRENERGIC BLOCKADE

1967 ◽  
Vol 11 (2) ◽  
pp. 99???100
Author(s):  
P. G. GAAL ◽  
A. A. KATTUS ◽  
A. KOLIN ◽  
G. ROSS
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
Before And After

scholarly journals Effect of beta‐adrenergic blockade on coronary blood flow during isometric exercise in older adults (875.7)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Amanda Ross ◽  
Zhaohui Gao ◽  
Matthew Heffernan ◽  
Urs Leuenberger ◽  
Lawrence Sinoway ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Isometric Exercise ◽  
Adrenergic Blockade ◽  
Beta Adrenergic

Primate gastric circulation: effects of catecholamines and adrenergic blockade

1976 ◽  
Vol 230 (2) ◽  
pp. 346-350 ◽  
Author(s):  
MJ Zinner ◽  
JC Kerr ◽  
DG Reynolds
Keyword(s):  
Blood Flow ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Gastric Blood Flow ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
Before And After ◽  
Gastric Circulation ◽  
Autoregulatory Escape ◽  
Upper Gastrointestinal

The effects of intra-arterial injections and infusions of epinephrine, norepinephrine, and isoproterenol on gastric blood flow were studied in anesthetized baboons. Blood flow was measured electromagnetically before and after adrenergic blockade. The results for injected epinephrine and norepinephrine indicate these agents to be pure vasoconstrictors in the primate gastric circulation, and this response is attenuated by alpha-adrenergic blockade with phenoxybenzamine. Isoproterenol is a pure vasodilator, and its response is attenuated following beta-adrenergic blockade with propranolol. Intra-arterial infusions of epinephrine and norepinephrine (.05 mug kg-1 min-1) resulted in sustained vasoconstriction with no evidence of autoregulatory escape and no postinfusion "over-shoot." This study suggests that epinephrine and norepinephrine might provide alternatives to vasopressin as a vasoconstrictor for the control of upper gastrointestinal bleeding.

Effect of Beta-Adrenergic Blockade on Coronary Blood Flow

1968 ◽  
Vol 2 (1) ◽  
pp. 63-67 ◽  
Author(s):  
P. D. Stein ◽  
H. L. Brooks ◽  
J. L. Matson ◽  
J. W. Hyland
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Adrenergic Blockade ◽  
Beta Adrenergic

alpha-Adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs

1982 ◽  
Vol 242 (5) ◽  
pp. H805-H809 ◽  
Author(s):  
G. R. Heyndrickx ◽  
P. Muylaert ◽  
J. L. Pannier
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Coronary Blood Flow ◽  
Coronary Sinus ◽  
Oxygen Delivery ◽  
Left Ventricular ◽  
Conscious Dogs ◽  
Adrenergic Blockade ◽  
Adrenergic Control

alpha-Adrenergic control of the oxygen delivery to the myocardium during exercise was investigated in eight conscious dogs instrumented for chronic measurements of coronary blood flow, left ventricular (LV) pressure, aortic blood pressure, and heart rate and sampling of arterial and coronary sinus blood. After alpha-adrenergic receptor blockade a standard exercise load elicited a significantly greater increase in heart rate, rate of change of LV pressure (LV dP/dt), LV dP/dt/P, and coronary blood flow than was elicited in the unblocked state. In contrast to the response pattern during control exercise, there was no significant change in coronary sinus oxygen tension (PO2), myocardial arteriovenous oxygen difference, and myocardial oxygen delivery-to-oxygen consumption ratio. It is concluded that the normal relationship between myocardial oxygen supply and oxygen demand is modified during exercise after alpha-adrenergic blockade, whereby oxygen delivery is better matched to oxygen consumption. These results indicate that the increase in coronary blood flow and oxygen delivery to the myocardium during normal exercise is limited by alpha-adrenergic vasoconstriction.

Alteration in myocardial oxygen balance during exercise after beta-adrenergic blockade in dogs

1980 ◽  
Vol 49 (1) ◽  
pp. 28-33 ◽  
Author(s):  
G. R. Heyndrickx ◽  
J. L. Pannier ◽  
P. Muylaert ◽  
C. Mabilde ◽  
I. Leusen
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Myocardial Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Sinus ◽  
Myocardial Oxygen Consumption ◽  
Left Ventricular ◽  
Adrenergic Blockade ◽  
Oxygen Balance

The effects of beta-adrenergic blockade upon myocardial blood flow and oxygen balance during exercise were evaluated in eight conscious dogs, instrumented for chronic measurements of coronary blood flow, left ventricular pressure, aortic blood pressure, heart rate, and sampling of arterial and coronary sinus venous blood. The administration of propranolol (1.5 mg/kg iv) produced a decrease in heart rate, peak left ventricular (LV) dP/dt, LV (dP/dt/P, and an increase in LV end-diastolic pressure during exercise. Mean coronary blood flow and myocardial oxygen consumption were lower after propranolol than at the same exercise intensity in control conditions. The oxygen delivery-to-oxygen consumption ratio and the coronary sinus oxygen content were also significantly lower. It is concluded that the relationship between myocardial oxygen supply and demand is modified during exercise after propranolol, so that a given level of myocardial oxygen consumption is achieved with a proportionally lower myocardial blood flow and a higher oxygen extraction.

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