Magnesium Sulfate Compared With Nifedipine for Acute Tocolysis of Preterm Labor: A Randomized-controlled Trial

2008 ◽  
Vol 28 (1) ◽  
pp. 21-22
Author(s):  
D.J. Lyell ◽  
K. Pullen ◽  
L. Campbell ◽  
S. Ching ◽  
M.L. Druzin ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Controlled Trial ◽  
Randomized Controlled

Magnesium Sulfate Compared with Nifedipine for Acute Tocolysis of Preterm Labor: A Randomized Controlled Trial

2007 ◽  
Vol 62 (11) ◽  
pp. 696-697
Author(s):  
Deirdre J. Lyell ◽  
Kristen Pullen ◽  
Laura Campbell ◽  
Suzanne Ching ◽  
Maurice L. Druzin ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Yasuyuki Kawagoe ◽  
Hiroshi Sameshima ◽  
Tsuyomu Ikenoue ◽  
Ichiro Yasuhi ◽  
Tatsuhiko Kawarabayashi
Keyword(s):  
Randomized Controlled Trial ◽  
Combination Therapy ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Uterine Contraction ◽  
Controlled Trial ◽  
Second Line ◽  
Uterine Contractions ◽  
Randomized Controlled ◽  
Tocolytic Agent

Objectives. We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours.Materials and Methods. A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficiently inhibit uterine contractions. After excluding 12 women, 33 were randomly assigned to either magnesium alone or combination (ritodrine and magnesium). The treatment was determined as effective if the frequency of uterine contraction was reduced by 30% at 48 hours of the treatment.Results. After magnesium sulfate infusion, 90% prolonged their pregnancy for >48 hours. Combination therapy was effective in 95% (18/19), which was significantly higher than 50% (7/14) for magnesium alone.Conclusion. This randomized trial revealed that combination therapy significantly reduced uterine contractions, suggesting that adjuvant magnesium with ritodrine is recommended, rather than changing into magnesium alone, when uterine contractions are intractable with ritodrine infusion.

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