[PP.23.06] PREDICTORS OF BLOOD PRESSURE RESPONSE IN THE NON-INVASIVE RENAL DENERVATION STUDY USING EXTERNALLY DELIVERED FOCUSED ULTRASOUND IN SEVERE RESISTANT HYPERTENSION

2016 ◽  
Vol 34 ◽  
pp. e255
Author(s):  
C. OTT ◽  
O. Dawood ◽  
Z. Starek ◽  
P. Kay ◽  
T. Anderson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Focused Ultrasound ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Non Invasive

scholarly journals Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension

2017 ◽  
Vol 19 (11) ◽  
pp. 1125-1133 ◽  
Author(s):  
Esther de Beus ◽  
Rosa L. de Jager ◽  
Martine M. Beeftink ◽  
Margreet F. Sanders ◽  
Wilko Spiering ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Salt Intake ◽  
Blood Pressure Response ◽  
Pressure Response

Resistant hypertension: Multivariate predictors of blood pressure response to renal denervation

2013 ◽  
Vol 168 (3) ◽  
pp. 3130-3132 ◽  
Author(s):  
Dirk Prochnau ◽  
Stefan Heymel ◽  
Björn Göbel ◽  
Hans R. Figulla ◽  
Ralf Surber
Keyword(s):  
Blood Pressure ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Blood Pressure Response ◽  
Pressure Response

Renal artery anatomy affects the blood pressure response to renal denervation in patients with resistant hypertension

2016 ◽  
Vol 202 ◽  
pp. 388-393 ◽  
Author(s):  
Dagmara Hering ◽  
Petra Marusic ◽  
Antony S. Walton ◽  
Jacqueline Duval ◽  
Rebecca Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Blood Pressure Response ◽  
Pressure Response

Abstract 13272: Efficacy and Safety of Non-invasive Renal Denervation Study Using Externally Delivered Focused Ultrasound in Severe Resistant Hypertension

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Roland E Schmieder ◽  
John A Ormiston ◽  
Petr Neuzil ◽  
Zdenek Stárek ◽  
Patrick Kay ◽  
...  
Keyword(s):  
Resistant Hypertension ◽  
Renal Denervation ◽  
Focused Ultrasound ◽  
Surrounding Tissue ◽  
Renal Nerves ◽  
Antihypertensive Medications ◽  
Serious Adverse Events ◽  
Sound System ◽  
Invasive Approach ◽  
Non Invasive

Background: Invasive catheter based techniques for renal denervation have been extensively examined in treating patients with resistant hypertension, with mixed results and some periprocedural complications. New evidence suggested that not all renal nerves are in the range of invasive procedures limited to a distance 4 to 6 mm from the lumen. Aims: To evaluate the safety and efficacy of an entirely non-invasive approach to renal denervation using externally delivered focused ultrasound to the peri-renal artery tissue with real time Doppler-based image guidance. Methods and results: Twenty-seven patients with severe, treatment resistant hypertension, defined as persistent systolic blood pressure (BP) > 160 mmHg despite 3 or more antihypertensive medications, were treated non-invasively with the Kona Medical Surround Sound System™. Focused ultrasound energy was delivered to the renal arteries bilaterally and surrounding tissue using Doppler-based imaging and continuous tracking with automatic correction for kidney motion throughout treatment. Patients received conscious sedation during the treatment period. At this time, all patients have completed 24 weeks and 23 patients 52 weeks of follow up. Post-denervation, the mean changes from baseline BP (175/92 mmHg) were -16.8/-8.6 mmHg at 3 weeks, -23.2/-10.8 mmHg at 6 weeks, -29.7/-13.1 mmHg at 12 weeks, -21.6/-8.7 mmHg at 24 weeks and -25.6/-10.1 mmHg at 52 weeks . No serious device-related events have been reported to date. Forty-one percent of subjects (11/27) reported mild back pain immediately following the denervation treatment. The majority of cases (7/11) completely resolved within three days post treatment without any significant intervention and no case was associated with any motor, sensory deficits. Conclusions: This is the first study in humans using a non-invasive renal denervation system in severe resistant hypertension. Results showed clinically meaningful reductions from baseline in office BP through 52 weeks post-denervation. The procedure was well-tolerated with no serious adverse events. This technology should enable patients to benefit from renal denervation therapy without the invasive risks associated with catheter based techniques.

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