Frequency–Amplitude Ratio of Ocular Vestibular-Evoked Myogenic Potentials for Detecting Meniere’s Disease

Meniere’s disease is a disorder of the inner ear resulting in symptoms of episodic vertigo, tinnitus, hearing loss and aural pressure. Although the exact etiology is uncertain, it is associated with raised pressure in the endolymph of the inner ear (endolymphatic hydrops). The diagnosis of Meniere's disease is based on the clinical setting of the patient. This disease usually presents with unilateral ear symptoms but can be also bilateral. Meniere's disease attacks are usually random and episodic (approximately 6-11 per year), with periods of remission that can last from months to years. Investigations are audiometry, electronystagmogram, vestibular evoked myogenic potentials (VEMPs) and imaging.The management consist pharmacological and non pharmacological. Meniere's disease is initially progressive but fluctuates unexpectedly. It is difficult to distinguish natural resolutions from treatment effects.

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Faculty Opinions recommendation of Altered frequency dynamics of cervical and ocular vestibular evoked myogenic potentials in patients with Ménière's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717951624.793456926 ◽

2012 ◽

Author(s):

Joseph Furman

Keyword(s):

Meniere’S Disease ◽

Menière’S Disease ◽

Vestibular Evoked Myogenic Potentials ◽

Meniere's Disease ◽

Ménière’S Disease ◽

Menière's Disease ◽

Ménière's Disease

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Electrocochleography in Retrosigmoid Vestibular Nerve Section for Intractable Vertigo Caused by Meniere's Disease

Otolaryngology ◽

10.1016/s0194-5998(97)70233-x ◽

1997 ◽

Vol 116 (6) ◽

pp. 593-596 ◽

Cited By ~ 1

Author(s):

Wesley W. O. Krueger ◽

Ian S. Storper

Keyword(s):

Amplitude Ratio ◽

Meniere’S Disease ◽

Vestibular Nerve ◽

Menière’S Disease ◽

Meniere's Disease ◽

Ménière’S Disease ◽

Menière's Disease ◽

Nerve Section ◽

Summating Potential ◽

Ménière's Disease

Interest in electrocochleography has increased in recent years because of the discovery of an elevated summating potential to action potential amplitude ratio (SP/AP ratio) in patients with endolymphatic hydrops caused by Meniere's disease or perilymph fistula. It was the purpose of this investigation to determine whether the intraoperative SP/AP ratio will decrease after vestibular nerve section in patients with intractable Meniere's disease. Fourteen patients with medically intractable classic Meniere's disease underwent retrosigmoid vestibular nerve section. Intraoperative transtympanic electrocochleography was performed with alternating click stimuli presented at 95 dB HL. In all patients the SP/AP ratio was recorded before the skin incision (“baseline” condition) and after the dura was closed (“closing” condition). Statistical analysis was applied to the recorded data. In 11 (79%) patients, the SP/AP ratio was found to be elevated above 0.30 in the baseline state. In 13 (93%) patients, the SP/AP ratio decreased more than 25% after the nerve was sectioned. These results were highly statistically significant (p < 0.001). We conclude that the SP/AP ratio does decrease in patients with Meniere's disease after undergoing retrosigmoid vestibular nerve section and offer a possible explanation. (Otolaryngol Head Neck Surg 1997;116:593–6.)

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Use of electrocochleography to monitor antigenic challenge in Meniere's disease

Otolaryngology ◽

10.1177/019459988910700604.1 ◽

1992 ◽

Vol 107 (6_part_1) ◽

pp. 733-737 ◽

Cited By ~ 13

Author(s):

George J. Viscomi ◽

Dennis I. Bojrab

Keyword(s):

Hearing Loss ◽

Amplitude Ratio ◽

Meniere’S Disease ◽

Menière’S Disease ◽

Meniere's Disease ◽

Ménière’S Disease ◽

Subjective Symptoms ◽

Menière's Disease ◽

Antigenic Challenge ◽

Ménière's Disease

Allergy has been reported as a cause of Meniere's disease. King et al. have established the validity of the provocative food test (PFT) for the diagnosis of food allergy. When the PFT is used to fest patients with Meniere's disease, the test is considered positive If the patient develops aural fullness, hearing loss, increased tinnitus, or dizziness during challenge with the offending food and relief of these symptoms during neutralization. Ferraro et al. have shown that electrocochleography (ECoG) provides an objective indication of subjective symptoms In Meniere's disease by demonstrating an Increased SP/AP amplitude ratio when the symptoms of aural fullness and hearing loss are present. We present several patients with Meniere's disease In whom measurement of the SP/AP amplitude ratio was compared with symptom production during antigenic challenge and neutralization.

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