Proton Beam Therapy for Locally Advanced Head and Neck Tumors

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Saad Sheikh ◽  
Michael Z. Kharouta ◽  
Rajesh Pidikiti ◽  
Nicholas J. Damico ◽  
Serah Choi ◽  
...  
2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17554-e17554
Author(s):  
Irina V. Aedinova ◽  
M. N. Chernyak ◽  
Yulia Ulianova ◽  
Viktoriya L. Volkova ◽  
Natalia A. Chertova ◽  
...  

e17554 Background: Treatment of locally advanced head and neck tumors is an extremely difficult task. Preoperative polychemotherapy allows improving the efficiency of combined treatment in most cases. We performed 6 chemoembolization procedures for locally advanced head and neck cancer in order to increase the effectiveness of chemotherapy with minimal systemic side effects and to reach cytostatic concentrations in tumors higher than at their intravenous administration. Methods: We performed the standard puncture femoral approach and selective catheterization of the external carotid artery followed by angiography. Superselective catheterization of targeted vessels using 2.6 F microcatheter was performed after evaluation of blood supply to the affected area. Chemoembolization was performed with platinum drugs (cisplatin at a mean dose of 50 mg/m2) in an oil emulsion with Lipiodol (4 patients) and saturable microspheres (2 patients). Results: All patients showed a severe pain syndrome during embolization with its increase by the evening of the day and its regression on the third day after surgery; general toxic symptoms were not observed. Significant perioperative complications were not registered. A marked necrosis of the tongue base tumor was observed in one patient after 10 days. All patients showed a partial positive response to the therapy which allowed radical surgical treatment. Conclusions: Chemoembolization with polymeric microspheres provides a longer (up to one month) contact between malignant cells and antitumor agents; chemoembolization is not accompanied by the development of adverse reactions and complications or immunosuppressive effect which allows its use in the most serious cases.


2000 ◽  
Vol 176 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Katja Hesse ◽  
Bernhard Heinrich ◽  
Frank Zimmermann ◽  
Reinhard Kau ◽  
Gabriele Sommer ◽  
...  

Author(s):  
Moshe H. Maor ◽  
David H. Hussey ◽  
Gilbert H. Fletcher ◽  
Richard H. Jesse

2002 ◽  
Vol 122 (5) ◽  
pp. 561-564 ◽  
Author(s):  
Manfred Muhm ◽  
Matthaeus Ch. Grasl ◽  
Martin Burian ◽  
Aris Exadaktylos ◽  
Michael Staudacher ◽  
...  

1996 ◽  
Vol 40 ◽  
pp. S166
Author(s):  
J. Maldonado ◽  
J. Giralt ◽  
N. Carballo ◽  
J.M. Del Campo ◽  
E. Felip ◽  
...  

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