A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment

Richard L. Rauck; Martin E. Hale; Almasa Bass; Candace Bramson; Glenn Pixton; Jacquelyn G. Wilson; Beatrice Setnik; Paul Meisner; Kenneth W. Sommerville; Bimal K. Malhotra; Gernot Wolfram

doi:10.1097/j.pain.0000000000000230

A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment

Pain ◽

10.1097/j.pain.0000000000000230 ◽

2015 ◽

Vol 156 (9) ◽

pp. 1660-1669 ◽

Cited By ~ 16

Author(s):

Richard L. Rauck ◽

Martin E. Hale ◽

Almasa Bass ◽

Candace Bramson ◽

Glenn Pixton ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Pain Treatment ◽

Low Back ◽

Efficacy And Safety ◽

Safety Study ◽

Double Blind ◽

Double Blind Placebo

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Efficacy and safety of oxymorphone extended release in chronic low back pain: Results of a randomized, double-blind, placebo- and active-controlled phase III study

Journal of Pain ◽

10.1016/j.jpain.2004.09.005 ◽

2005 ◽

Vol 6 (1) ◽

pp. 21-28 ◽

Cited By ~ 110

Author(s):

Martin E. Hale ◽

Chris Dvergsten ◽

Joseph Gimbel

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Phase Iii ◽

Low Back ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Phase Iii Study

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Efficacy and Safety of OPANA ER (Oxymorphone Extended Release) for Relief of Moderate to Severe Chronic Low Back Pain in Opioid-Experienced Patients: A 12-Week, Randomized, Double-blind, Placebo-controlled Study

Journal of Pain ◽

10.1016/j.jpain.2006.09.011 ◽

2007 ◽

Vol 8 (2) ◽

pp. 175-184 ◽

Cited By ~ 110

Author(s):

Martin E. Hale ◽

Harry Ahdieh ◽

Tina Ma ◽

Richard Rauck

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Controlled Study ◽

Low Back ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo

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Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

Expert Opinion on Pharmacotherapy ◽

10.1517/14656566.2010.497720 ◽

2010 ◽

Vol 11 (11) ◽

pp. 1787-1804 ◽

Cited By ~ 162

Author(s):

Robert Buynak ◽

Douglas Y Shapiro ◽

Akiko Okamoto ◽

Ilse Van Hove ◽

Christine Rauschkolb ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Phase Iii ◽

Low Back ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Phase Iii Study

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(454) A randomized, double-blind, placebo-controlled, multicenter trial to assess the efficacy and safety of oxycodone/naloxone extended-release tablets (OXN) in opioid-experienced subjects with chronic low back pain

Journal of Pain ◽

10.1016/j.jpain.2014.01.365 ◽

2014 ◽

Vol 15 (4) ◽

pp. S89 ◽

Cited By ~ 1

Author(s):

J. Green ◽

B. Dain ◽

C. Munera ◽

J. Gimbel ◽

J. Potts ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Multicenter Trial ◽

Low Back ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo

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708 RESULTS OF A RANDOMIZED, DOUBLE‐BLIND, PLACEBO‐AND ACTIVE‐CONTROLLED TRIAL OF TAPENTADOL EXTENDED RELEASE FOR CHRONIC LOW BACK PAIN

European Journal of Pain ◽

10.1016/s1090-3801(09)60711-4 ◽

2009 ◽

Vol 13 (S1) ◽

Cited By ~ 1

Author(s):

D.Y. Shapiro ◽

R. Buynak ◽

A. Okamoto ◽

I. Hove ◽

A. Steup ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Controlled Trial ◽

Low Back ◽

Double Blind ◽

Double Blind Placebo

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Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study

Current Medical Research and Opinion ◽

10.1185/03007995.2012.726216 ◽

2012 ◽

Vol 28 (10) ◽

pp. 1617-1634 ◽

Cited By ~ 19

Author(s):

Michael A. Überall ◽

Gerhard H.H. Mueller-Schwefe ◽

Bernd Terhaag

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Low Back ◽

Modified Release ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Parallel Group ◽

Phase Iv

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(248) Analgesic efficacy and safety of controlled-release hydrocodone and acetaminophen tablets, dosed twice daily, for moderate to severe mechanical chronic low-back pain: A randomized, double-blind, placebo-controlled withdrawal trial

Journal of Pain ◽

10.1016/j.jpain.2008.01.169 ◽

2008 ◽

Vol 9 (4) ◽

pp. 38

Author(s):

C. Codding ◽

D. Levinsky ◽

M. Hale ◽

J. Thomas ◽

E. Lockhart ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Controlled Release ◽

Chronic Low Back Pain ◽

Analgesic Efficacy ◽

Low Back ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo

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(443) Low risk of diversion in a randomized, double-blind, placebo-controlled study of extended-release hydrocodone tablets formulated with abuse-deterrence technology for the treatment chronic low back pain

Journal of Pain ◽

10.1016/j.jpain.2015.01.362 ◽

2015 ◽

Vol 16 (4) ◽

pp. S86

Author(s):

M. Hale ◽

T. Zimmerman ◽

E. Eyal ◽

R. Malamut

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Extended Release ◽

Low Risk ◽

Controlled Study ◽

Low Back ◽

Double Blind ◽

Double Blind Placebo

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Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety

Pain ◽

10.1097/j.pain.0000000000001928 ◽

2020 ◽

Vol 161 (9) ◽

pp. 2068-2078 ◽

Cited By ~ 2

Author(s):

John D. Markman ◽

Robert B. Bolash ◽

Timothy E. McAlindon ◽

Alan J. Kivitz ◽

Manuel Pombo-Suarez ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Low Back ◽

Efficacy And Safety ◽

Phase 3 ◽

Double Blind ◽

Double Blind Placebo

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(259) Efficacy of oxymorphone extended release in opioid-experienced patients with chronic low back pain due to a herniated disc: Subgroup analysis of a randomized, double-blind, placebo-controlled trial

Journal of Pain ◽

10.1016/j.jpain.2008.01.180 ◽

2008 ◽

Vol 9 (4) ◽

pp. 40

Author(s):

M. Hale ◽

T. Ma ◽

H. Ahdieh ◽

R. Kerwin

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Subgroup Analysis ◽

Chronic Low Back Pain ◽

Extended Release ◽

Controlled Trial ◽

Herniated Disc ◽

Low Back ◽

Double Blind ◽

Double Blind Placebo

Download Full-text