Neurotoxicity of BFM-95 on the Medial Olivocochlear Bundle Assessed by Means of Contralateral Suppression of 2f1-f2 Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 28 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Maria Riga ◽  
Stavros Korres ◽  
Ioannis Psarommatis ◽  
Maria Varvutsi ◽  
Ioannis Giotakis ◽  
...  
Author(s):  
Ana Carolina dos Santos ◽  
Ludimila Labanca ◽  
Larissa Resende Assumpção ◽  
Patricia Cotta Mancini ◽  
Sirley Alves da Silva Carvalho ◽  
...  

Abstract Introduction Distortion product otoacoustic emissions (DPOAE) and their suppression may be considered useful in monitoring cochlear function and the efferent auditory pathway inhibitory effect. Nonetheless, the establishment of reliable parameters of response variations is of great importance. Objectives To verify the replicability of test and retest in the research of the inhibitory effect of the efferent pathway using contralateral suppressing stimulus during DPOAE recording for clinical applicability. Methods Cross-sectional study with 48 volunteers, aged 18 to 30 years, with normal audiometric thresholds. The procedures included were audiometric and immittance measures to overrule any conductive or sensorineural conditions and DPOAE recordings without and with contralateral suppression with a 60 dBHL white noise. Distortion product otoacoustic emissions amplitudes were analyzed and compared in both conditions with Wilcoxon test, and the Spearman correlation test was used to assess test-retest reliability. Results The comparative analysis showed differences between amplitudes in test and retest conditions only in 1,500 Hz for DPOAE measures with all other tested frequencies showing no differences, and no difference was observed in all recorded frequencies in the test and retest comparison for DPOAE suppression. The degree of correlation between test and retest of DPOAE amplitude was good at 6,000 Hz and strong (r > 0.880) at the other frequencies. For DPOAE with suppression, all frequencies presented strong correlation between test and retest: 1,500 Hz (r = 0.880), 2,000 Hz (r = 0.882), 3,000 Hz (r = 0.940), and 6,000 Hz (r = 0.957). Conclusions The study found good replicability in contralateral suppression of DPOAE with potential clinical applicability, and we recommend conducting the test from 2000Hz to higher frequencies for more reliable results.


2019 ◽  
Vol 28 (2S) ◽  
pp. 508-515
Author(s):  
L. Yashaswini ◽  
Sandeep Maruthy

Purpose The study aimed to assess the relationship between the level-dependent function of efferent inhibition and speech perception in noise across different intensities of suppressor and across different signal-to-noise ratios (SNRs) of speech. Method Twenty-six young normal-hearing adults participated in the study. Contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) was measured for 3 levels of suppressor (40, 50, and 60 dB SPL). Speech identification score (SIS) was measured at 5 ipsilateral SNR conditions (quiet, 0, −5, −10, and −15 dB), with and without contralateral broadband noise at 3 levels (40, 50, and 60 dB SPL). Furthermore, SNR-50 was measured with and without the same 3 levels of contralateral broadband noise. Results The results showed that the suppression magnitude of TEOAE increased with an increase in suppressor level. However, neither SIS nor SNR-50 was influenced by the contralateral noise. In addition, SIS and SNR-50 did not show significant correlation with contralateral suppression of TEOAEs. This was true at all the SNRs and contralateral noise levels used in the study. Conclusions The findings suggest that the intensity of noise directly influences medial olivocochlear bundle–mediated efferent inhibition. However, the role of the medial olivocochlear bundle in regulating speech perception in noise needs to be revisited. Supplemental Material https://doi.org/10.23641/asha.9336353


2017 ◽  
Vol 15 (2) ◽  
pp. 72-75
Author(s):  
Prashanth Prabhu ◽  
Prajwal Kumar ◽  
Swati Goyal ◽  
Gowtham Varma ◽  
Kristi Kaveri Dutta

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