Bartonella quintana-induced Vulval Bacillary Angiomatosis

2012 ◽  
Vol 31 (4) ◽  
pp. 390-394 ◽  
Author(s):  
Pratistadevi K. Ramdial ◽  
Yetish Sing ◽  
Amsha Ramburan ◽  
Ncoza C. Dlova ◽  
Jayanthilall S. Bagratee ◽  
...  
1996 ◽  
Vol 27 (1) ◽  
pp. 101
Author(s):  
D. Pierard ◽  
A. De Coninck ◽  
G. Muyldermans ◽  
P. Lacor ◽  
J. Andre ◽  
...  

2008 ◽  
Vol 77 (1) ◽  
pp. 307-316 ◽  
Author(s):  
Nermi L. Parrow ◽  
Jasmin Abbott ◽  
Amanda R. Lockwood ◽  
James M. Battisti ◽  
Michael F. Minnick

ABSTRACT Bartonella quintana is a gram-negative agent of trench fever, chronic bacteremia, endocarditis, and bacillary angiomatosis in humans. B. quintana has the highest known hemin requirement among bacteria, but the mechanisms of hemin acquisition are poorly defined. Genomic analyses revealed a potential locus dedicated to hemin utilization (hut) encoding a putative hemin receptor, HutA; a TonB-like energy transducer; an ABC transport system comprised of three proteins, HutB, HutC, and HmuV; and a hemin degradation/storage enzyme, HemS. Complementation analyses with Escherichia coli hemA show that HutA functions as a hemin receptor, and complementation analyses with E. coli hemA tonB indicate that HutA is TonB dependent. Quantitative reverse transcriptase PCR analyses show that hut locus transcription is subject to hemin-responsive regulation, which is mediated primarily by the iron response regulator (Irr). Irr functions as a transcriptional repressor of the hut locus at all hemin concentrations tested. Overexpression of the ferric uptake regulator (fur) represses transcription of tonB in the presence of excess hemin, whereas overexpression of the rhizobial iron regulator (rirA) has no effect on hut locus transcription. Reverse transcriptase PCR analyses show that hutA and tonB are divergently transcribed and that the remaining hut genes are expressed as a polycistronic mRNA. Examination of the promoter regions of hutA, tonB, and hemS reveals consensus sequence promoters that encompass an H-box element previously shown to interact with B. quintana Irr.


2021 ◽  
Vol 20 (2) ◽  
pp. 147-150
Author(s):  
Malihe Hassan Nezhad ◽  
Saber Esmaeili ◽  
Seyed Ahmad Seyed Alinaghi ◽  
Ladan Abbasian ◽  
Tahmine Biazar ◽  
...  

2011 ◽  
Vol 60 (1) ◽  
pp. 142-146 ◽  
Author(s):  
Natasha E. Holmes ◽  
Stephen Opat ◽  
Anthony Kelman ◽  
Tony M. Korman

Bacillary angiomatosis is a well-recognized infection with cutaneous and systemic manifestations caused by Bartonella henselae or Bartonella quintana and occurs in immunocompromised patients. We report a case of B. quintana bacillary angiomatosis following fludarabine-based chemotherapy for chronic lymphocytic leukaemia that was refractory to standard treatment and was complicated by lymphadenopathy and osteomyelitis.


2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Rosamaria Fulchini ◽  
Guido Bloemberg ◽  
Katia Boggian

We present a 63-year-old man treated with alemtuzumab for chronic lymphocytic leukemia who developed multiple angiomatous papules and fever. Real-time polymerase chain reaction (RT-PCR) from a skin lesion and blood sample revealedBartonella quintanaas causative agent confirming the diagnosis of bacillary angiomatosis with bacteremia. Treatment with doxycycline, initially in combination with gentamicin, led to complete resolution of the lesions. This case shows the importance of considering bacillary angiomatosis as a rare differential diagnosis of angiomatous lesions in the immunocompromised patient, particularly in chronic lymphocytic leukemia and following lymphocyte depleting treatments as alemtuzumab.


2000 ◽  
Vol 42 (2) ◽  
pp. 299-301 ◽  
Author(s):  
Raquel Santosa ◽  
Orlando Cardosob ◽  
Paulo Rodriguesb ◽  
Jorge Cardosoa ◽  
João Machadob ◽  
...  

1998 ◽  
Vol 20 (6) ◽  
pp. 593
Author(s):  
A. Afonso ◽  
R. Santos ◽  
O. Cardoso ◽  
P. Rodrígues ◽  
J. Cardoso ◽  
...  

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