scholarly journals Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging

2018 ◽  
Author(s):  
James A. Winkelmann ◽  
Aya Eid ◽  
Graham Spicer ◽  
Luay M. Almassalha ◽  
The-Quyen Nguyen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visible Light ◽  
Lymphatic Vessel ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Spectral Signatures ◽  
Spectral Contrast ◽  
Endogenous Contrast ◽  
Tissue Discrimination ◽  
Vessel Imaging

AbstractOptical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.

scholarly journals Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
James A. Winkelmann ◽  
Aya Eid ◽  
Graham Spicer ◽  
Luay M. Almassalha ◽  
The-Quyen Nguyen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Spectral Contrast ◽  
Vessel Imaging

scholarly journals Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

2020 ◽  
Author(s):  
Weiye Song ◽  
Wenjun Shao ◽  
Wei Yi ◽  
Rongrong Liu ◽  
Manishi Desai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visible Light ◽  
Optical Coherence Tomography Angiography ◽  
Spectral Power ◽  
Spectral Power Density ◽  
Optical Coherence ◽  
Imaging Protocol ◽  
Spectral Contrast ◽  
Accurate Localization ◽  
Acquisition Speed

AbstractWe report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the imaging protocol such that a single acquisition takes <6 seconds with a field of view (FOV) of 3×7.8 mm2. The angiography enables accurate localization of microvasculature down to the capillary level and thus enables oximetry at vessels < 100 μm in diameter. We demonstrated microvascular hemoglobin oxygen saturation (sO2) at the feeding and draining vessels at the perifoveal region. The longitudinal repeatability was assessed by <5% coefficient of variation (CV). The unique capabilities of our vis-OCTA system may allow studies on the role of microvascular oxygen in various retinal pathologies.

Optical coherence tomography angiography in ophthalmology: an application in vessel imaging

2021 ◽  
Author(s):  
Anadi Khatri ◽  
Araniko Pandey ◽  
Gunjan Prasai ◽  
Kinsuk Singh ◽  
Muna Kharel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Vessel Imaging
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