scholarly journals Mapping short-latency cortical responses to electrical stimulation of thalamic motor nuclei by increasing sampling rate - a technical report

2019 ◽  
Author(s):  
Emilia Toth ◽  
Ganne Chaitanya ◽  
Sandipan Pati

AbstractDirect electrical stimulation (DES) of the cortex is a clinically indispensable brain mapping technique that provides reliable information about the distribution of eloquent cortex and its connectivity to the white matter bundles. Here we present a technical report on mapping the short latency cortical responses to stimulation of the ventral anterior nucleus of human thalamus. Reliable downstream responses were noted in the regions connected to the ventral anterior nucleus i.e. superior and inferior frontal gyri, supplementary motor area and limbic substructures (cingulate gyrus and hippocampus).

NeuroImage ◽  
2007 ◽  
Vol 34 (2) ◽  
pp. 743-763 ◽  
Author(s):  
R. Dowman ◽  
T. Darcey ◽  
H. Barkan ◽  
V. Thadani ◽  
D. Roberts

2018 ◽  
Vol 361 ◽  
pp. 23-35 ◽  
Author(s):  
Christopher J. Pastras ◽  
Ian S. Curthoys ◽  
Ljiljana Sokolic ◽  
Daniel J. Brown

Epilepsia ◽  
2007 ◽  
Vol 48 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Siew-Na Lim ◽  
Shih-Tseng Lee ◽  
Yu-Tai Tsai ◽  
I-An Chen ◽  
Po-Hsun Tu ◽  
...  

2014 ◽  
Vol 111 (5) ◽  
pp. 1077-1087 ◽  
Author(s):  
Craig A. Atencio ◽  
Jonathan Y. Shih ◽  
Christoph E. Schreiner ◽  
Steven W. Cheung

Cochlear implant electrical stimulation of the auditory system to rehabilitate deafness has been remarkably successful. Its deployment requires both an intact auditory nerve and a suitably patent cochlear lumen. When disease renders prerequisite conditions impassable, such as in neurofibromatosis type II and cochlear obliterans, alternative treatment targets are considered. Electrical stimulation of the cochlear nucleus and midbrain in humans has delivered encouraging clinical outcomes, buttressing the promise of central auditory prostheses to mitigate deafness in those who are not candidates for cochlear implantation. In this study we explored another possible implant target: the auditory thalamus. In anesthetized cats, we first presented pure tones to determine frequency preferences of thalamic and cortical sites. We then electrically stimulated tonotopically organized thalamic sites while recording from primary auditory cortical sites using a multichannel recording probe. Cathode-leading biphasic thalamic stimulation thresholds that evoked cortical responses were much lower than published accounts of cochlear and midbrain stimulation. Cortical activation dynamic ranges were similar to those reported for cochlear stimulation, but they were narrower than those found through midbrain stimulation. Our results imply that thalamic stimulation can activate auditory cortex at low electrical current levels and suggest an auditory thalamic implant may be a viable central auditory prosthesis.


Acute Pain ◽  
2007 ◽  
Vol 9 (1) ◽  
pp. 47
Author(s):  
R. Dowman ◽  
T. Darcey ◽  
H. Barkan ◽  
V. Thadani ◽  
D. Roberts

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